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Review
. 2009:84:35-48.
doi: 10.1016/S0074-7742(09)00403-6.

Cerebrovascular and cardiovascular pathology in Alzheimer's disease

Jack C de la Torre  1
Affiliations
Review

Cerebrovascular and cardiovascular pathology in Alzheimer's disease

Jack C de la Torre. Int Rev Neurobiol. 2009.

Abstract

Presently, compelling evidence indicates that Alzheimer's disease (AD) is a vascular disorder with neurodegenerative consequences and should be treated as such. A substantial body of evidence including epidemiological, pharmacotherapeutic, and neuroimaging studies support the concept of AD as a vascular disorder or vasocognopathy that initiates as brain hypoperfusion, creating a neuronal energy crisis. The neuronal energy crisis provokes the cellular and molecular changes that characterize this dementia. In this brief review, the many vascular-related risk factors to AD including some that are preventable or amenable to treatment are discussed. Considerable human data now point in a new direction for guiding future research into AD. This new research direction should open a window of opportunity for decisive management and treatment of this devastating disorder.

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