Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Aug 28;284(35):23177-81.
doi: 10.1074/jbc.R109.021006. Epub 2009 Jun 1.

Type II transmembrane serine proteases

Thomas H Bugge  1 , Toni M Antalis, Qingyu Wu
Affiliations
Review

Type II transmembrane serine proteases

Thomas H Bugge et al. J Biol Chem. .

Abstract

Analysis of genome and expressed sequence tag data bases at the turn of the millennium unveiled a new protease family named the type II transmembrane serine proteases (TTSPs) in a Journal of Biological Chemistry minireview (Hooper, J. D., Clements, J. A., Quigley, J. P., and Antalis, T. M. (2001) J. Biol. Chem. 276, 857-860). Since then, the number of known TTSPs has more than doubled, and more importantly, our understanding of the physiological functions of individual TTSPs and their contribution to human disease has greatly increased. Progress has also been made in identifying molecular substrates and endogenous inhibitors. This minireview summarizes the current knowledge of the rapidly advancing TTSP field.

PubMed Disclaimer

Figures

FIGURE 1.
FIGURE 1.
The TTSP family is composed of four subfamilies: HAT/DESC, hepsin/TMPRSS, matriptase, and corin. The structure of each TTSP is shown schematically. TTSPs consist of an N-terminal signal anchor domain (S.A.) and a C-terminal trypsin-like serine protease domain (Serine) that flank a stem region composed of 1–11 protein domains of six different types (see box at bottom). The location of each domain (amino acid numbering) is indicated above the domain (4). HAT-like 2 and HAT-like 3 are found in rodents but not in primates. Polyserase has three C-terminal serine protease domains, of which the third is catalytically inactive. Scavenger indicates the group A scavenger receptor domain.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hooper J. D., Clements J. A., Quigley J. P., Antalis T. M. (2001) J. Biol. Chem. 276,857–860 - PubMed
    1. Szabo R., Wu Q., Dickson R. B., Netzel-Arnett S., Antalis T. M., Bugge T. H. (2003) Thromb. Haemost. 90,185–193 - PubMed
    1. Quesada V., Ordóñez G. R., Sánchez L. M., Puente X. S., López-Otín C. (2009) Nucleic Acids Res. 37,D239–243 - PMC - PubMed
    1. Szabo R., Bugge T. H. (2008) Int. J. Biochem. Cell Biol. 40,1297–1316 - PubMed
    1. Takeuchi T., Harris J. L., Huang W., Yan K. W., Coughlin S. R., Craik C. S. (2000) J. Biol. Chem. 275,26333–26342 - PubMed

Publication types

LinkOut - more resources