Review
doi: 10.1016/j.bbadis.2009.01.008.
Epub 2009 Jan 27.
Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss
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- PMID: 19419706
- DOI: 10.1016/j.bbadis.2009.01.008
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Review
Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss
Biochim Biophys Acta.
2009 Apr.
Free article
Abstract
Marrow stromal cells (MSC) are thought to be stem cells with osteogenic potential and therefore responsible for the repair and maintenance of the skeleton. Age related bone loss is one of the most prevalent diseases in the elder population. It is controversial whether MSC undergo a process of aging in vivo, leading to decreased ability to form and maintain bone homeostasis with age. In this review we summarize evidence of MSC involvement in age related bone loss and suggest new emerging targets for intervention.
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