Comment
doi: 10.1073/pnas.0903024106.
Epub 2009 Apr 22.
Amplification of signaling via cellular allosteric relay and protein disorder
Affiliations
- PMID: 19416924
- PMCID: PMC2678435
- DOI: 10.1073/pnas.0903024106
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Comment
Amplification of signaling via cellular allosteric relay and protein disorder
Proc Natl Acad Sci U S A.
.
No abstract available
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Nanoscale allosteric signal transduction relay from the cell surface to the nucleus. (A) Allosteric proteins and cell signaling. The simplified GPCR-cAMP-CRP and GPCR-cAMP-PKA-CREB pathways represent short routes connecting extracellular stimuli to the nucleus via the cytoplasm. Cytoplasmic proteins often display an on/off transmission switch, like the PKA and scaffold MAPK systems. (B) Allosteric relay in signal transduction can be nanoscale, over hundreds of nanometers.
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References
-
- Changeux JP, Edelstein SJ. Allosteric mechanisms of signal transduction. Science. 2005;308:1424–1428. - PubMed
-
- Goodey NM, Benkovic SJ. Allosteric regulation and catalysis emerge via a common route. Nat Chem Biol. 2008;4:474–482. - PubMed
-
- Gunasekaran K, Ma B, Nussinov R. Is allostery an intrinsic property of all dynamic proteins? Proteins. 2004;57:433–443. - PubMed
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