IL-17-producing T cells in lung immunity and inflammation
- PMID: 19410688
- DOI: 10.1016/j.jaci.2009.03.033
IL-17-producing T cells in lung immunity and inflammation
Abstract
T(H)17 cells are a recently described effector CD4 T-cell subset characterized by the production of IL-17A, IL-17F, and IL-22, which have been implicated in the pathogenesis of several autoimmune diseases. T(H)17 and other IL-17A-producing T cells, including a population of gammadelta T cells and natural killer T cells, have also been associated with the development of skin, intestinal, and lung inflammatory diseases, such as asthma, granulomatous disease, chronic obstructive pulmonary disease, and cystic fibrosis. On the other hand, IL-17-producing T cells play important roles in protective immunity against some bacterial infections, mainly through the recruitment and activation of neutrophils. Thus, their regulation appears to be critical, and excess or deficient IL-17 elaboration leads either to deficient responses or disease. This review will summarize T(H)17 cell differentiation and discuss the host beneficial and detrimental function of IL-17A and related cytokines produced by different subpopulations of T cells.
Similar articles
-
Development and function of TH17 cells in health and disease.J Allergy Clin Immunol. 2009 May;123(5):1004-11. doi: 10.1016/j.jaci.2009.04.003. J Allergy Clin Immunol. 2009. PMID: 19410689 Review.
-
The roles of IL-17A in inflammatory immune responses and host defense against pathogens.Immunol Rev. 2008 Dec;226:57-79. doi: 10.1111/j.1600-065X.2008.00699.x. Immunol Rev. 2008. PMID: 19161416 Review.
-
Th17 cytokines and their emerging roles in inflammation and autoimmunity.Immunol Rev. 2008 Dec;226:87-102. doi: 10.1111/j.1600-065X.2008.00712.x. Immunol Rev. 2008. PMID: 19161418 Review.
-
IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis.J Immunol. 2010 Jun 1;184(11):6367-77. doi: 10.4049/jimmunol.0900459. Epub 2010 Apr 26. J Immunol. 2010. PMID: 20421647
-
Induction, function and regulation of IL-17-producing T cells.Eur J Immunol. 2008 Oct;38(10):2636-49. doi: 10.1002/eji.200838535. Eur J Immunol. 2008. PMID: 18958872 Review.
Cited by
-
Downregulation of integrin β4 decreases the ability of airway epithelial cells to present antigens.PLoS One. 2012;7(4):e32060. doi: 10.1371/journal.pone.0032060. Epub 2012 Apr 24. PLoS One. 2012. PMID: 22545078 Free PMC article.
-
Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation.Mol Immunol. 2013 Dec;56(4):480-7. doi: 10.1016/j.molimm.2013.05.228. Epub 2013 Aug 1. Mol Immunol. 2013. PMID: 23911404 Free PMC article.
-
Regulatory T cell and macrophage crosstalk in acute lung injury: future perspectives.Cell Death Discov. 2023 Jan 16;9(1):9. doi: 10.1038/s41420-023-01310-7. Cell Death Discov. 2023. PMID: 36646692 Free PMC article. Review.
-
Interleukin-17A enhances host defense against cryptococcal lung infection through effects mediated by leukocyte recruitment, activation, and gamma interferon production.Infect Immun. 2014 Mar;82(3):937-48. doi: 10.1128/IAI.01477-13. Epub 2013 Dec 9. Infect Immun. 2014. PMID: 24324191 Free PMC article.
-
Th17 can regulate silica-induced lung inflammation through an IL-1β-dependent mechanism.J Cell Mol Med. 2014 Sep;18(9):1773-84. doi: 10.1111/jcmm.12341. Epub 2014 Aug 5. J Cell Mol Med. 2014. PMID: 25091058 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
