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Review
. 2009 May 11;206(5):977-80.
doi: 10.1084/jem.20090765. Epub 2009 Apr 20.

A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme

Barbara A Malynn  1 , Averil Ma
Affiliations
Review

A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme

Barbara A Malynn et al. J Exp Med. .

Abstract

Many B cell cancers are characterized in part by the dysregulation of the NF-kappaB signaling pathway. A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-kappaB inhibitor A20, in Hodgkin lymphomas and primary mediastinal lymphomas. These data reveal the role of A20 as a tumor suppressor protein.

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