Estrogen, aging and the cardiovascular system
- PMID: 19371207
- PMCID: PMC3972065
- DOI: 10.2217/14796678.5.1.93
Estrogen, aging and the cardiovascular system
Abstract
Estrogen is a powerful hormone with pleiotropic effects. Estrogens have potent antioxidant effects and are able to reduce inflammation, induce vasorelaxation and alter gene expression in both the vasculature and the heart. Estrogen treatment of cultured cardiac myocytes and endothelial cells rapidly activates NFkappaB, induces heat-shock protein (HSP)-72, a potent intracellular protective protein, and protects cells from simulated ischemia. In in vivo models, estrogens protect against ischemia and trauma/hemorrhage. Estrogens may decrease the expression of soluble epoxide hydrolase, which has deleterious effects on the cardiovascular system through metabolism of epoxyeicosatrienoic acids. Natural (endogenous) estrogens in premenopausal women appear to protect against cardiovascular disease and yet controlled clinical trials have not indicated a benefit from estrogen replacement postmenopause. Much remains to be understood in regards to the many properties of this powerful hormone and how changes in this hormone interact with aging-associated changes. The unexpected negative results of trials of estrogen replacement postmenopause probably arise from our lack of understanding of the many effects of this hormone.
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References
Bibliography
-
- Mendelsohn ME, Karas RH. Molecular and cellular basis of cardiovascular gender differences. Science. 2005;308:1583–1587. - PubMed
-
- Murphy E, Steenbergen C. Cardioprotection in females: a role for nitric oxide and altered gene expression. Heart Fail Rev. 2007;12:293–300. - PubMed
-
- Choudhry MA, Chaudry IH. 17β-estradiol: a novel hormone for improving immune and cardiovascular responses following trauma-hemorrhage. J Leukoc Biol. 2008;83:518–522. - PubMed
-
- Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med. 1999;340:1801–1811. An insightful paper summarizing the beneficial effects of 17β-estradiol (E2) on the cardiovascular system. - PubMed
-
- Ferrari AU, Radaelli A, Centola M. Invited review: aging and the cardiovascular system. J Appl Physiol. 2003;95:2591–2597. - PubMed
Website
-
- American Association of Clinical Endocrinologists (AACE) position statement on hormone replacement therapy (HRT) and cardiovascular risk. 2008 www.aace.com/pub/pdf/guidelines/HRTCVRISKposition_statement.pdf.
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