Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans
- PMID: 19349290
- DOI: 10.1158/1940-6207.CAPR-08-0192
Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans
Abstract
The isothiocyanate sulforaphane [SF; 1-isothiocyanato-4(R)-methylsulfinylbutane] is abundant in broccoli sprouts in the form of its glucosinolate precursor (glucoraphanin). SF is powerfully bactericidal against Helicobacter pylori infections, which are strongly associated with the worldwide pandemic of gastric cancer. Oral treatment with SF-rich broccoli sprouts of C57BL/6 female mice infected with H. pylori Sydney strain 1 and maintained on a high-salt (7.5% NaCl) diet reduced gastric bacterial colonization, attenuated mucosal expression of tumor necrosis factor-alpha and interleukin-1beta, mitigated corpus inflammation, and prevented expression of high salt-induced gastric corpus atrophy. This therapeutic effect was not observed in mice in which the nrf2 gene was deleted, strongly implicating the important role of Nrf2-dependent antioxidant and anti-inflammatory proteins in SF-dependent protection. Forty-eight H. pylori-infected patients were randomly assigned to feeding of broccoli sprouts (70 g/d; containing 420 micromol of SF precursor) for 8 weeks or to consumption of an equal weight of alfalfa sprouts (not containing SF) as placebo. Intervention with broccoli sprouts, but not with placebo, decreased the levels of urease measured by the urea breath test and H. pylori stool antigen (both biomarkers of H. pylori colonization) and serum pepsinogens I and II (biomarkers of gastric inflammation). Values recovered to their original levels 2 months after treatment was discontinued. Daily intake of sulforaphane-rich broccoli sprouts for 2 months reduces H. pylori colonization in mice and improves the sequelae of infection in infected mice and in humans. This treatment seems to enhance chemoprotection of the gastric mucosa against H. pylori-induced oxidative stress.
Similar articles
-
[Effects of sulforaphane-rich broccoli sprouts on H. pylori-infected gastric mucosa].Nihon Rinsho. 2005 Nov;63 Suppl 11:582-6. Nihon Rinsho. 2005. PMID: 16363606 Clinical Trial. Japanese. No abstract available.
-
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.Proc Natl Acad Sci U S A. 2002 May 28;99(11):7610-5. doi: 10.1073/pnas.112203099. Proc Natl Acad Sci U S A. 2002. PMID: 12032331 Free PMC article.
-
Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in vitro, and demonstrates anti-inflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects.Curr Pharm Des. 2011;17(16):1532-40. doi: 10.2174/138161211796196945. Curr Pharm Des. 2011. PMID: 21548875
-
Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress.Curr Pharm Des. 2017;23(27):4066-4075. doi: 10.2174/1381612823666170207103943. Curr Pharm Des. 2017. PMID: 28176666 Free PMC article. Review.
-
Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress.Inflammopharmacology. 2005;13(1-3):83-90. doi: 10.1163/156856005774423863. Inflammopharmacology. 2005. PMID: 16259730 Review.
Cited by
-
Phytonutrients in the promotion of healthspan: a new perspective.Front Nutr. 2024 Jul 12;11:1409339. doi: 10.3389/fnut.2024.1409339. eCollection 2024. Front Nutr. 2024. PMID: 39070259 Free PMC article. Review.
-
Lactational transfer of sulforaphane-N-acetylcysteine in vivo and in human breast milk.Toxicol Appl Pharmacol. 2024 Jan;482:116796. doi: 10.1016/j.taap.2023.116796. Epub 2023 Dec 23. Toxicol Appl Pharmacol. 2024. PMID: 38145809 Free PMC article.
-
Natural foods resources and dietary ingredients for the amelioration of Helicobacter pylori infection.Front Med (Lausanne). 2023 Dec 6;10:1324473. doi: 10.3389/fmed.2023.1324473. eCollection 2023. Front Med (Lausanne). 2023. PMID: 38131043 Free PMC article. Review.
-
The Rationale for Sulforaphane Favourably Influencing Gut Homeostasis and Gut-Organ Dysfunction: A Clinician's Hypothesis.Int J Mol Sci. 2023 Aug 30;24(17):13448. doi: 10.3390/ijms241713448. Int J Mol Sci. 2023. PMID: 37686253 Free PMC article.
-
Anticancer properties of sulforaphane: current insights at the molecular level.Front Oncol. 2023 Jun 16;13:1168321. doi: 10.3389/fonc.2023.1168321. eCollection 2023. Front Oncol. 2023. PMID: 37397365 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical