Comparative Study
doi: 10.1016/0092-8674(91)90066-8.
The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination
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- PMID: 1934069
- DOI: 10.1016/0092-8674(91)90066-8
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Comparative Study
The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination
Cell.
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Abstract
Roughened is a dominant mutation of D. melanogaster that disrupts eye development. The majority of the ommatidia in the adult eye lack a single photoreceptor cell, which is most commonly the R7 cell. The Roughened mutation disrupts the early stages of photoreceptor cell determination. Roughened is a dominant gain-of-function mutation that results from a single amino acid change (Phe157 to Leu) in the Drosophila Rap1 protein. Loss of function Rap1 mutations are lethal. Drosophila Rap1 protein is 88% identical to human rap1A/K-rev1 protein, a putative antagonist of ras action.
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