Review
doi: 10.1016/j.coi.2009.02.007.
Epub 2009 Mar 25.
Preclinical development of T cell receptor gene therapy
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- PMID: 19321326
- DOI: 10.1016/j.coi.2009.02.007
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Review
Preclinical development of T cell receptor gene therapy
Curr Opin Immunol.
2009 Apr.
Abstract
The adoptive transfer of TCR gene-modified T cells has been developed with the aim to induce immune reactivity toward defined tumor-associated antigens to which the endogenous T cell repertoire is non-responsive. Here we discuss in which areas preclinical studies in mouse models can or cannot be expected to be of value to guide clinical trial design, and how the available data from preclinical studies should influence forthcoming clinical trials.
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