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Comparative Study
. 2009 Feb;64(1):51-7.
doi: 10.2143/AC.64.1.2034362.

Cell-free DNA levels in acute myocardial infarction patients during hospitalization

Aspasia Destouni  1 , Christina Vrettou, Dionisis Antonatos, George Chouliaras, Joanne Traeger-Synodinos, Sotiris Patsilinakos, Sophia Kitsiou-Tzeli, Dimitrios Tsigas, Emmanouel Kanavakis
Affiliations
Comparative Study

Cell-free DNA levels in acute myocardial infarction patients during hospitalization

Aspasia Destouni et al. Acta Cardiol. 2009 Feb.

Abstract

Objectives: The objectives of this study were to investigate cell-free DNA daily concentration changes following an acute myocardial infarction (AMI) and to assess any correlations with complications during hospitalization.

Methods and results: Serial cell-free DNA level determinations were performed by quantitative Real-Time PCR in 47 AMI patients once daily during hospitalization (235 samples) and once in 100 healthy subjects. Cell-free DNA concentrations are significantly higher in patients throughout hospitalization compared to healthy subject levels (2.644 (SE 0.0952) vs. 1.519 (SE 0.0566), P < 0.001). The median maximum cell-free DNA concentration was 3.5-fold higher (Mann Whitney P = 0.0035) in 20/47 patients with complicated post AMI course--group I--(1719.7, range 117.32-4996212.1 GenEq/ml plasma) compared with 27/47 patients without complications--group II--(492.9, range 56.43-4715.15 GenEq/ml plasma). Substantial differences exist between cell-free DNA concentrations measured on t(pre) (the day before the complication) and t(c) (the day the complication occurred) as well as t(post) (the day after the complication) in group I whereby cell-free DNA rises significantly in t(c) and remains elevated in t(post) (t(pre) vs. t(c), 2.445 vs. 2.965, P = 0.0171 and t(pre) vs. t(post) 2.445 vs. 2.913, P = 0.023).

Conclusions: Cell-free DNA concentrations were elevated in AMI patients compared to healthy control subjects, rise significantly when complications occur and have a potential clinical value in monitoring patient progress during hospitalization.

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