Recent topics related to human herpesvirus 6 cell tropism
- PMID: 19290911
- DOI: 10.1111/j.1462-5822.2009.01312.x
Recent topics related to human herpesvirus 6 cell tropism
Abstract
Human herpesvirus 6 (HHV-6) is a T lymphotropic herpes virus that is categorized into two variants, A (HHV-6A) and B (HHV-6B), on the basis of distinct genetic, immunological and biological characteristics. HHV-6 uses human CD46 as a cellular receptor. Without viral replication, HHV-6A induces cell-cell fusion between cells expressing human CD46. Some HHV-6B strains can also induce CD46-mediated cell-cell fusion. A multiple glycoprotein complex composed of glycoprotein (g) H-gL complexed with gQ1 and gQ2 has been identified, and found to be a viral ligand for the human CD46 receptor. Moreover, a novel complex consisting of gH/gL/gO, which does not associate with CD46, has also been identified. The evidence suggests that an additional receptor for HHV-6B or both variants may play a role in determining the cell tropism of this virus. Finally, cholesterol in the HHV-6 envelope and plasma membrane of the host cells plays an important role in HHV-6 entry, although how this function relates to cell-envelope fusion remains to be elucidated.
Similar articles
-
Complexities in human herpesvirus-6A and -6B binding to host cells.Virology. 2006 Dec 5-20;356(1-2):1-3. doi: 10.1016/j.virol.2006.07.028. Epub 2006 Sep 7. Virology. 2006. PMID: 16959284 Review.
-
Human herpesvirus-6A gQ1 and gQ2 are critical for human CD46 usage.Microbiol Immunol. 2014 Jan;58(1):22-30. doi: 10.1111/1348-0421.12110. Microbiol Immunol. 2014. PMID: 24215487
-
Human herpesvirus-6 entry into host cells.Future Microbiol. 2010 Jul;5(7):1015-23. doi: 10.2217/fmb.10.61. Future Microbiol. 2010. PMID: 20632802 Review.
-
Induction of cell-cell fusion from without by human herpesvirus 6B.J Virol. 2006 Oct;80(19):9916-20. doi: 10.1128/JVI.02693-05. J Virol. 2006. PMID: 16973598 Free PMC article.
-
Human herpesvirus-6 infection induces the reorganization of membrane microdomains in target cells, which are required for virus entry.Virology. 2008 Sep 1;378(2):265-71. doi: 10.1016/j.virol.2008.05.028. Epub 2008 Jul 14. Virology. 2008. PMID: 18621409
Cited by
-
The role of the complement system in Multiple Sclerosis: A review.Front Immunol. 2022 Aug 10;13:970486. doi: 10.3389/fimmu.2022.970486. eCollection 2022. Front Immunol. 2022. PMID: 36032156 Free PMC article. Review.
-
Complementation of the function of glycoprotein H of human herpesvirus 6 variant A by glycoprotein H of variant B in the virus life cycle.J Virol. 2012 Aug;86(16):8492-8. doi: 10.1128/JVI.00504-12. Epub 2012 May 30. J Virol. 2012. PMID: 22647694 Free PMC article.
-
Herpes virus fusion and entry: a story with many characters.Viruses. 2012 May;4(5):800-32. doi: 10.3390/v4050800. Epub 2012 May 10. Viruses. 2012. PMID: 22754650 Free PMC article. Review.
-
Chemokines encoded by herpesviruses.J Leukoc Biol. 2017 Nov;102(5):1199-1217. doi: 10.1189/jlb.4RU0417-145RR. Epub 2017 Aug 28. J Leukoc Biol. 2017. PMID: 28848041 Free PMC article. Review.
-
Structural basis for the interaction of human herpesvirus 6B tetrameric glycoprotein complex with the cellular receptor, human CD134.PLoS Pathog. 2020 Jul 17;16(7):e1008648. doi: 10.1371/journal.ppat.1008648. eCollection 2020 Jul. PLoS Pathog. 2020. PMID: 32678833 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
