Review
doi: 10.1016/j.sbi.2009.02.003.
Epub 2009 Mar 13.
Structural biology of the p53 tumour suppressor
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- PMID: 19286366
- DOI: 10.1016/j.sbi.2009.02.003
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Review
Structural biology of the p53 tumour suppressor
Curr Opin Struct Biol.
2009 Apr.
Abstract
The p53 tumour suppressor protein has presented a challenge for structural biology for more than two decades. The complete p53 molecule has eluded numerous attempts to determine its structure, presumably owing to the intrinsic conformational flexibility that is essential to the protein's function. Recent data obtained by X-ray crystallography, NMR spectroscopy and electron microscopy provide new insight into the quaternary architecture of the whole molecule and new strategies for examining how these structures correlate with the cell and molecular biology of the 'Guardian of the Genome'.
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