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. 2009;6(2):65-71.
doi: 10.7150/ijms.6.65. Epub 2009 Feb 26.

Esterified hyaluronic acid and autologous bone in the surgical correction of the infra-bone defects

Andrea Ballini  1 , Stefania Cantore, Saverio Capodiferro, Felice Roberto Grassi
Affiliations

Esterified hyaluronic acid and autologous bone in the surgical correction of the infra-bone defects

Andrea Ballini et al. Int J Med Sci. 2009.

Abstract

We study the osteoinductive effect of the hyaluronic acid (HA) by using an esterified low-molecular HA preparation (EHA) as a coadjuvant in the grafting processes to produce bone-like tissue in the presence of employing autologous bone obtained from intra-oral sites, to treat infra-bone defects without covering membrane. We report on 9 patients with periodontal defects treated by EHA and autologous grafting (4 males and 5 females, all non smokers, with a mean age of 43.8 years for females, 40.0 years for males and 42 years for all the group, in good health) with a mean depth of 8.3 mm of the infra-bone defects, as revealed by intra-operative probes. Data were obtained at baseline before treatment and after 10 days, and subsequently at 6, 9, and 24 months after treatment. Clinical results showed a mean gain hi clinical attachment (gCAL) of 2.6mm of the treated sites, confirmed by radiographic evaluation. Such results suggest that autologous bone combined with EHA seems to have good capabilities in accelerating new bone formation in the infra-bone defects.

Keywords: Guided tissue regeneration; Hyaluronic acid; biomaterials.; bone graft.

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Conflict of interest statement

Conflict of Interest: The authors declare that they have no competing interests.

Figures

Fig 1
Fig 1
Pre-operative periapical radiography
Fig 2
Fig 2
Initial probing
Fig 3
Fig 3
Surgical flap
Fig 4
Fig 4
Flap elevation, intra-surgical evaluation of the parameters and surgical curettage of the intra-osseous defect
Fig 5
Fig 5
Autogenous bone graft harvested by a mini-bone scraper (Safescraper curve or Micross)
Fig 6
Fig 6
Autogenous bone graft mixed with Hyaloss® matrix
Fig 7
Fig 7
Flap replacement and nylon 4-0 single stitches sutures.
Fig 8
Fig 8
Flap replacement and nylon 4-0 single stitches sutures.
Fig 9
Fig 9
Clinical re-evaluation 10 days after surgery
Fig 10
Fig 10
Clinical re-evaluation 6 months after surgery
Fig 11
Fig 11
Radiographic re-evaluation 6 months from surgery
Fig 12
Fig 12
Clinical re-evaluation 9 months after surgery
Fig 13
Fig 13
Radiographic follow up at 9 months after surgery
Fig 14
Fig 14
Clinical re-evaluation 24 months after surgery
Fig 15
Fig 15
Radiographic follow up at 24 months after surgery
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