Review
doi: 10.2174/187152609787847695.
Drug targets in rhinoviral infections
Affiliations
- PMID: 19275701
- DOI: 10.2174/187152609787847695
Item in Clipboard
Review
Drug targets in rhinoviral infections
Infect Disord Drug Targets.
2009 Apr.
Abstract
Human Rhinoviruses (HRV) are by far the most common respiratory viruses responsible for most cases of the common cold and important pathogens in acute exacerbations of asthma and COPD. The molecular pathogenesis of HRV infection is quite completely understood. However there is still no approved specific treatment against HRV infections. The aim of this article is therefore to give an overview of the principles of rhinovirus infection, the associated therapeutic targets and to review up-to-date virus-specific clinical trials.
Similar articles
-
Rhinovirus chemotherapy.Antiviral Res. 2006 Sep;71(2-3):391-6. doi: 10.1016/j.antiviral.2006.03.011. Epub 2006 Apr 18. Antiviral Res. 2006. PMID: 16675037 Free PMC article. Review.
-
Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model.Sci Rep. 2016 Mar 15;6:23110. doi: 10.1038/srep23110. Sci Rep. 2016. PMID: 26976677 Free PMC article.
-
Antiviral activity of gemcitabine against human rhinovirus in vitro and in vivo.Antiviral Res. 2017 Sep;145:6-13. doi: 10.1016/j.antiviral.2017.07.003. Epub 2017 Jul 11. Antiviral Res. 2017. PMID: 28705625
-
α1-Antitrypsin reduces rhinovirus infection in primary human airway epithelial cells exposed to cigarette smoke.Int J Chron Obstruct Pulmon Dis. 2016 Jun 10;11:1279-86. doi: 10.2147/COPD.S105717. eCollection 2016. Int J Chron Obstruct Pulmon Dis. 2016. PMID: 27354786 Free PMC article.
-
Recent advances in the treatment of rhinovirus infections.Curr Opin Pharmacol. 2001 Oct;1(5):477-81. doi: 10.1016/s1471-4892(01)00083-2. Curr Opin Pharmacol. 2001. PMID: 11764773 Review.
Cited by
-
Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection.Mar Drugs. 2019 Jun 22;17(6):373. doi: 10.3390/md17060373. Mar Drugs. 2019. PMID: 31234532 Free PMC article. Review.
-
Rhinovirus Inhibitors: Including a New Target, the Viral RNA.Viruses. 2021 Sep 7;13(9):1784. doi: 10.3390/v13091784. Viruses. 2021. PMID: 34578365 Free PMC article. Review.
-
Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology.Clin Microbiol Rev. 2010 Jan;23(1):74-98. doi: 10.1128/CMR.00032-09. Clin Microbiol Rev. 2010. PMID: 20065326 Free PMC article. Review.
-
Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo.Antimicrob Agents Chemother. 2013 Jul;57(7):3358-68. doi: 10.1128/AAC.00303-13. Epub 2013 May 6. Antimicrob Agents Chemother. 2013. PMID: 23650168 Free PMC article.
-
Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold.Respir Res. 2010 Aug 10;11(1):108. doi: 10.1186/1465-9921-11-108. Respir Res. 2010. PMID: 20696083 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
