Review
doi: 10.1016/j.ceb.2009.01.023.
Epub 2009 Feb 23.
Recent mechanistic insights into eukaryotic ribosomes
Affiliations
- PMID: 19243929
- DOI: 10.1016/j.ceb.2009.01.023
Item in Clipboard
Review
Recent mechanistic insights into eukaryotic ribosomes
Curr Opin Cell Biol.
2009 Jun.
Abstract
Ribosomes are supramolecular ribonucleoprotein particles that synthesize proteins in all cells. Protein synthesis proceeds through four major phases: initiation, elongation, termination, and ribosome recycling. In each phase, a number of phase-specific translation factors cooperate with the ribosome. Whereas elongation in prokaryotes and eukaryotes involve similar factors and proceed by similar mechanisms, mechanisms of initiation, termination, and ribosome recycling, as well as the factors involved, appear quite different. Here, we summarize recent progress in deciphering molecular mechanisms of eukaryotic translation. Comparisons with prokaryotic translation are included, emphasizing emerging patterns of common design.
Similar articles
-
[Termination of prokaryotic and eukaryotic translation].Postepy Biochem. 2007;53(4):420-30. Postepy Biochem. 2007. PMID: 19024906 Review. Polish.
-
Dissecting eukaryotic translation and its control by ribosome density mapping.Nucleic Acids Res. 2005 Apr 28;33(8):2421-32. doi: 10.1093/nar/gki331. Print 2005. Nucleic Acids Res. 2005. PMID: 15860778 Free PMC article.
-
Structure-function insights into prokaryotic and eukaryotic translation initiation.Curr Opin Struct Biol. 2009 Jun;19(3):300-9. doi: 10.1016/j.sbi.2009.04.010. Epub 2009 Jun 1. Curr Opin Struct Biol. 2009. PMID: 19493673 Review.
-
Evidence for in vivo ribosome recycling, the fourth step in protein biosynthesis.EMBO J. 1998 Feb 16;17(4):1141-51. doi: 10.1093/emboj/17.4.1141. EMBO J. 1998. PMID: 9463391 Free PMC article.
-
Evolution and the universality of the mechanism of initiation of protein synthesis.Gene. 2009 Mar 1;432(1-2):1-6. doi: 10.1016/j.gene.2008.11.001. Epub 2008 Nov 8. Gene. 2009. PMID: 19056476 Review.
Cited by
-
Birth, life and death of nascent polypeptide chains.Biotechnol J. 2011 Jun;6(6):623-40. doi: 10.1002/biot.201000327. Epub 2011 Apr 29. Biotechnol J. 2011. PMID: 21538896 Free PMC article. Review.
-
Ribosomal proteins as a possible tool for blocking SARS-COV 2 virus replication for a potential prospective treatment.Med Hypotheses. 2020 Oct;143:109904. doi: 10.1016/j.mehy.2020.109904. Epub 2020 May 30. Med Hypotheses. 2020. PMID: 32502901 Free PMC article.
-
Non-canonical Translation in Plant RNA Viruses.Front Plant Sci. 2017 Apr 6;8:494. doi: 10.3389/fpls.2017.00494. eCollection 2017. Front Plant Sci. 2017. PMID: 28428795 Free PMC article. Review.
-
Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.Genetics. 2016 May;203(1):65-107. doi: 10.1534/genetics.115.186221. Genetics. 2016. PMID: 27183566 Free PMC article. Review.
-
The ribosomal stalk protein is crucial for the action of the conserved ATPase ABCE1.Nucleic Acids Res. 2018 Sep 6;46(15):7820-7830. doi: 10.1093/nar/gky619. Nucleic Acids Res. 2018. PMID: 30010948 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
