The protective role of curcumin in cardiovascular diseases
- PMID: 19233493
- DOI: 10.1016/j.ijcard.2009.01.073
The protective role of curcumin in cardiovascular diseases
Abstract
Curcumin (diferuloylmethane) is a polyphenol responsible for the yellow color of the curry spice turmeric. It has been used in a variety of diseases in traditional medicine. Modern scientific research has demonstrated its anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-thrombotic, and cardiovascular protective effects. In this review, we focused mainly on the effects of curcumin on the cardiovascular system. The antioxidant effects of curcumin have been shown to attenuate adriamycin-induced cardiotoxicity and may prevent diabetic cardiovascular complications. The anti-thrombotic, anti-proliferative, and anti-inflammatory effects of curcumin and the effect of curcumin in decreasing the serum cholesterol level may protect against the pathological changes occurring with atherosclerosis. The p300-HAT inhibitory effects of curcumin have been demonstrated to ameliorate the development of cardiac hypertrophy and heart failure in animal models. The inflammatory effects of curcumin may have the possibility of preventing atrial arrhythmias and the possible effect of curcumin for correcting the Ca(2+) homeostasis may play a role in the prevention of some ventricular arrhythmias. The preclinical studies from animal to clinical data in human are discussed.
Similar articles
-
Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.Trends Pharmacol Sci. 2009 Feb;30(2):85-94. doi: 10.1016/j.tips.2008.11.002. Epub 2008 Dec 26. Trends Pharmacol Sci. 2009. PMID: 19110321 Review.
-
Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies.Br J Nutr. 2010 Jun;103(11):1545-57. doi: 10.1017/S0007114509993667. Epub 2010 Jan 26. Br J Nutr. 2010. PMID: 20100380 Review.
-
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.Mol Nutr Food Res. 2008 Sep;52(9):987-94. doi: 10.1002/mnfr.200700259. Mol Nutr Food Res. 2008. Retraction in: Mol Nutr Food Res. 2009 Feb;53(2):309. PMID: 18327875 Retracted. Review.
-
Challenges associated with curcumin therapy in Alzheimer disease.Expert Rev Mol Med. 2011 Nov 4;13:e34. doi: 10.1017/S1462399411002055. Expert Rev Mol Med. 2011. PMID: 22051121 Review.
-
Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity.J Agric Food Chem. 2008 Aug 13;56(15):6185-205. doi: 10.1021/jf8006568. Epub 2008 Jul 2. J Agric Food Chem. 2008. PMID: 18593176 Review.
Cited by
-
Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s).Evid Based Complement Alternat Med. 2015;2015:678218. doi: 10.1155/2015/678218. Epub 2015 May 3. Evid Based Complement Alternat Med. 2015. PMID: 26064170 Free PMC article.
-
Effects of curcumin on the apoptosis of cardiomyocytes and the expression of NF-κB, PPAR-γ and Bcl-2 in rats with myocardial infarction injury.Exp Ther Med. 2016 Dec;12(6):3877-3884. doi: 10.3892/etm.2016.3858. Epub 2016 Nov 2. Exp Ther Med. 2016. PMID: 28105120 Free PMC article.
-
Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy.Nutrients. 2017 Apr 21;9(4):414. doi: 10.3390/nu9040414. Nutrients. 2017. PMID: 28430129 Free PMC article.
-
Phytochemical Compounds and Protection from Cardiovascular Diseases: A State of the Art.Biomed Res Int. 2015;2015:918069. doi: 10.1155/2015/918069. Epub 2015 Oct 4. Biomed Res Int. 2015. PMID: 26504846 Free PMC article. Review.
-
Novel epigenetic-based therapies useful in cardiovascular medicine.World J Cardiol. 2016 Feb 26;8(2):211-9. doi: 10.4330/wjc.v8.i2.211. World J Cardiol. 2016. PMID: 26981216 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
