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Review
. 2008 Sep 12;26 Suppl 4(Suppl 4):D49-53.
doi: 10.1016/j.vaccine.2008.07.039.

The biology of influenza viruses

Nicole M Bouvier  1 , Peter Palese
Affiliations
Review

The biology of influenza viruses

Nicole M Bouvier et al. Vaccine. .

Abstract

The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure ofthe influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift. These processes result in viruses able to evade the long-term adaptive immune responses in many hosts.

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Figures

FIGURE 1
FIGURE 1. Ribbon diagram of an uncleaved hemagglutinin monomer from the 1918 influenza A virus (H1N1), the causative agent of the “Spanish flu” pandemic
The head contains the sialic acid receptor-binding site, which is surrounded by the five predicted antigenic sites (Sa, Sb, Ca1, Ca2, and Cb). The stem comprises helices A and B and the fusion peptide, as shown. (Adapted from a figure, kindly provided by James Stevens and Ian Wilson, in [1].)
See this image and copyright information in PMC

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References

    1. Palese P, Shaw ML. Orthomyxoviridae: The Viruses and their Replication. In: Knipe DM, Howley PM, editors. Fields Virology. Philadelphia: Lippincott Williams & Wilkins; 2007.
    1. Zebedee SL, Lamb RA. Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions. J Virol. 1988 Aug;62(8):2762–72. - PMC - PubMed
    1. Chen W, Calvo PA, Malide D, Gibbs J, Schubert U, Bacik I, et al. A novel influenza A virus mitochondrial protein that induces cell death. Nat Med. 2001 Dec;7(12):1306–12. - PubMed
    1. Hatta M, Kawaoka Y. The NB protein of influenza B virus is not necessary for virus replication in vitro. J Virol. 2003 May;77(10):6050–4. - PMC - PubMed
    1. Lamb RA, Lai CJ, Choppin PW. Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins. Proc Natl Acad Sci U S A. 1981 Jul;78(7):4170–4. - PMC - PubMed

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