doi: 10.1093/bioinformatics/btp091.
Epub 2009 Feb 19.
Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution
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- PMID: 19228802
- DOI: 10.1093/bioinformatics/btp091
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Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution
Bioinformatics.
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Abstract
Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size.
Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.
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