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Review
. 2009 Jan 29;61(2):160-7.
doi: 10.1016/j.neuron.2009.01.001.

MAP'ing CNS development and cognition: an ERKsome process

Ivy S Samuels  1 , Sulagna C Saitta, Gary E Landreth
Affiliations
Review

MAP'ing CNS development and cognition: an ERKsome process

Ivy S Samuels et al. Neuron. .

Abstract

The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autism. Here, we review recent studies that provide insight into the biological roles of the ERKs in the brain that may underlie the cognitive deficits seen in these syndromes.

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Figures

Figure 1
Figure 1
The ERK Signaling Cascade
Figure 2
Figure 2
ERK Activity Is Necessary for the Normal Development of Neural Crest and the Central Nervous System
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