Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Aug;73(4):472-7.

IL-8 causes in vivo neutrophil migration by a cell-dependent mechanism

R A Ribeiro  1 , C A Flores, F Q Cunha, S H Ferreira
Affiliations

IL-8 causes in vivo neutrophil migration by a cell-dependent mechanism

R A Ribeiro et al. Immunology. 1991 Aug.

Abstract

A dose-dependent neutrophil migration was observed following the injection of recombinant interleukin-8 (rIL-8) into rat peritoneal cavities. This finding contrasts with the inability of rIL-8 to induce neutrophil emigration into subcutaneous air-pouches. Pre-treatment of the animals with dexamethasone (0.5 mg/kg, s.c.) or depletion of the peritoneal resident cell population abolished the neutrophil migration induced by rIL-8 and by recombinant interleukin-1 beta (rIL-1 beta). Different from that which occurs with rIL-1 beta, neutrophil migration induced by rIL-8 was not enhanced by an increase in the peritoneal macrophage population. Transference of homologous total resident peritoneal cells to the air-pouch rendered this cavity responsive to the chemotactic effect of rIL-8 and potentiated the neutrophil migration induced by rIL-1. Our results show that both rIL-8 and rIL-1 beta are able to induce in vivo neutrophil migration by an indirect mechanism, dependent on resident cells. Neither macrophages nor lymphocytes seem to be involved in the rIL-8 chemotactic effect. However, peritoneal resident mast cells may be implicated in this mechanism. These cells, when stimulated in vitro by rIL-8, released a factor that when injected into peritoneal and air-pouch cavities induced neutrophil migration.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Immunol Methods. 1980;39(1-2):135-45 - PubMed
    1. J Pathol. 1981 Jun;134(2):147-56 - PubMed
    1. Int J Exp Pathol. 1990 Oct;71(5):717-25 - PubMed
    1. J Immunol. 1987 Nov 15;139(10):3474-83 - PubMed
    1. Br J Pharmacol. 1988 Aug;94(4):1143-8 - PubMed

LinkOut - more resources