RNA polymerase: regulation of transcript elongation and termination
- PMID: 1916107
- DOI: 10.1096/fasebj.5.13.1916107
RNA polymerase: regulation of transcript elongation and termination
Abstract
Expanded interest in studying the mechanisms of elongation and termination during transcription has come as a result of several recent findings that highlight the importance of the regulation of these processes in human health. Several cellular proto-oncogenes contain regulated blocks to elongation (1), and the human immunodeficiency viruses also control gene expression in part by regulating the efficiency of elongation in response to the trans-activating protein, TAT (2). This review considers these recent findings and compares potential mechanisms of regulation used by prokaryotic and eukaryotic RNA polymerases during elongation and termination. In all these systems, many of the detailed mechanisms of transcription elongation and termination are still to be defined; however, we have tried to group examples that may share some common regulatory elements into simplified categories.
Similar articles
-
Regulation of viral transcription elongation and termination during vaccinia virus infection.Biochim Biophys Acta. 2002 Sep 13;1577(2):325-36. doi: 10.1016/s0167-4781(02)00461-x. Biochim Biophys Acta. 2002. PMID: 12213661 Review.
-
The many conformational states of RNA polymerase elongation complexes and their roles in the regulation of transcription.Biochim Biophys Acta. 2002 Sep 13;1577(2):224-39. doi: 10.1016/s0167-4781(02)00454-2. Biochim Biophys Acta. 2002. PMID: 12213654 Review.
-
Specificity mechanisms in the control of transcription.Biophys Chem. 1996 Apr 16;59(3):231-46. doi: 10.1016/0301-4622(96)00006-3. Biophys Chem. 1996. PMID: 8672714 Review.
-
Transcription of genetic information and its regulation by protein factors.Angew Chem Int Ed Engl. 1972 Oct;11(10):883-93. doi: 10.1002/anie.197208831. Angew Chem Int Ed Engl. 1972. PMID: 4628292 Review. No abstract available.
-
Modular Organization of the NusA- and NusG-Stimulated RNA Polymerase Pause Signal That Participates in the Bacillus subtilis trp Operon Attenuation Mechanism.J Bacteriol. 2017 Jun 27;199(14):e00223-17. doi: 10.1128/JB.00223-17. Print 2017 Jul 15. J Bacteriol. 2017. PMID: 28507243 Free PMC article.
Cited by
-
The RNA polymerase II elongation complex. Factor-dependent transcription elongation involves nascent RNA cleavage.J Biol Chem. 1992 Aug 5;267(22):15516-22. J Biol Chem. 1992. PMID: 1379232 Free PMC article.
-
Cleavage of the nascent transcript induced by TFIIS is insufficient to promote read-through of intrinsic blocks to elongation by RNA polymerase II.Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8087-91. doi: 10.1073/pnas.91.17.8087. Proc Natl Acad Sci U S A. 1994. PMID: 8058762 Free PMC article.
-
The RNA polymerase II general elongation factors.Trends Biochem Sci. 1996 Sep;21(9):351-5. Trends Biochem Sci. 1996. PMID: 8870500 Free PMC article. Review.
-
A novel nuclear import pathway for the transcription factor TFIIS.J Cell Biol. 1998 Dec 14;143(6):1447-55. doi: 10.1083/jcb.143.6.1447. J Cell Biol. 1998. PMID: 9852143 Free PMC article.
-
Effects of heterologous downstream sequences on the activity of the HIV-1 promoter and its response to Tat.Nucleic Acids Res. 1997 Dec 15;25(24):5017-24. doi: 10.1093/nar/25.24.5017. Nucleic Acids Res. 1997. PMID: 9396810 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
