Renal tubulointerstitial fibrosis: common but never simple
- PMID: 19144691
- DOI: 10.1152/ajprenal.90521.2008
Renal tubulointerstitial fibrosis: common but never simple
Abstract
Regardless of etiology, all patients with chronic renal disease show a progressive decline in renal function with time. Fibrosis, so-called scarring, is a key cause of this pathophysiology. Fibrosis involves an excess accumulation of extracellular matrix (primarily composed of collagen) and usually results in loss of function when normal tissue is replaced with scar tissue. While recent major advances have led to a much better understanding of this process, many problems remain. We for instance know little about why some wounds heal and others scar and little about how many putative antifibrotic agents work. This review discusses recent advances in our understanding of the mechanisms of tubulointerstitial fibrosis, focusing on the regulation and role of the myofibroblast in this process, the role of recently recognized endogenous antifibrotic factors, controversy surrounding the effects of metalloproteinases, and the opportunities presented by new treatment strategies that abrogate and may even reverse fibrosis.
Similar articles
-
Cytokines in epithelial-mesenchymal transition: a new insight into obstructive nephropathy.J Urol. 2008 Aug;180(2):461-8. doi: 10.1016/j.juro.2008.04.001. Epub 2008 Jun 11. J Urol. 2008. PMID: 18550128 Review.
-
Mechanisms of tubulointerstitial fibrosis.J Am Soc Nephrol. 2010 Nov;21(11):1819-34. doi: 10.1681/ASN.2010080793. Epub 2010 Sep 23. J Am Soc Nephrol. 2010. PMID: 20864689 Review.
-
Relaxin regulates collagen overproduction associated with experimental progressive renal fibrosis.Ann N Y Acad Sci. 2005 May;1041:182-4. doi: 10.1196/annals.1282.026. Ann N Y Acad Sci. 2005. PMID: 15956704
-
Relaxin: an endogenous renoprotective factor?Ann N Y Acad Sci. 2009 Apr;1160:289-93. doi: 10.1111/j.1749-6632.2008.03795.x. Ann N Y Acad Sci. 2009. PMID: 19416206 Review.
-
Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis.Am J Pathol. 1996 Apr;148(4):1169-80. Am J Pathol. 1996. PMID: 8644858 Free PMC article.
Cited by
-
Can postpyelonephritic renal scarring be prevented?Pediatr Nephrol. 2013 Feb;28(2):187-90. doi: 10.1007/s00467-012-2334-2. Epub 2012 Oct 20. Pediatr Nephrol. 2013. PMID: 23086593
-
Ferulic Acid Attenuates TGF-β1-Induced Renal Cellular Fibrosis in NRK-52E Cells by Inhibiting Smad/ILK/Snail Pathway.Evid Based Complement Alternat Med. 2015;2015:619720. doi: 10.1155/2015/619720. Epub 2015 Apr 8. Evid Based Complement Alternat Med. 2015. PMID: 25949265 Free PMC article.
-
Zika Virus Infection Induces Acute Kidney Injury Through Activating NLRP3 Inflammasome Via Suppressing Bcl-2.Front Immunol. 2019 Aug 14;10:1925. doi: 10.3389/fimmu.2019.01925. eCollection 2019. Front Immunol. 2019. PMID: 31474993 Free PMC article.
-
tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling.Am J Pathol. 2010 Sep;177(3):1164-75. doi: 10.2353/ajpath.2010.091269. Epub 2010 Jul 16. Am J Pathol. 2010. PMID: 20639453 Free PMC article.
-
Induced autologous stem cell transplantation for treatment of rabbit renal interstitial fibrosis.PLoS One. 2013 Dec 18;8(12):e83507. doi: 10.1371/journal.pone.0083507. eCollection 2013. PLoS One. 2013. PMID: 24367598 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
