Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Feb;44(2):129-33.
doi: 10.1016/j.jcv.2008.11.006. Epub 2008 Dec 30.

Oropouche fever epidemic in Northern Brazil: epidemiology and molecular characterization of isolates

Helena B Vasconcelos  1 , Raimunda S S Azevedo, Samir M Casseb, Joaquim P Nunes-Neto, Jannifer O Chiang, Patrick C Cantuária, Maria N O Segura, Lívia C Martins, Hamilton A O Monteiro, Sueli G Rodrigues, Márcio R T Nunes, Pedro F C Vasconcelos
Affiliations

Oropouche fever epidemic in Northern Brazil: epidemiology and molecular characterization of isolates

Helena B Vasconcelos et al. J Clin Virol. 2009 Feb.

Abstract

Background: Oropouche fever virus is an important arbovirus associated with febrile disease that re-emerged in 2006 in several municipalities of Pará State, Bragantina region, Amazon, Brazil, 26 years after the last epidemic.

Objective: To investigate an Oropouche fever outbreak in this region.

Study design: A serologic survey and prospective study of acute febrile cases were performed in Magalhães Barata (urban and rural areas) and Maracanã (rural area) municipalities. Serology (IgM-ELISA and hemagglutination-inhibition [HI]), virus isolation, RT-PCR and real-time-PCR were used to confirm Oropouche virus (OROV) as responsible for the febrile outbreaks.

Results: Real-time-PCR showed high titers of OROV in acute-phase serum samples from febrile patients. From 113 of 119 acutely febrile patients with paired serum samples, OROV infections was confirmed by serologic conversion (n=76) or high titers (n=37) for both HI and IgM-ELISA. Patients had a febrile disease characterized by headache, chills, dizziness, photophobia, myalgia, nausea, and vomiting. Females and children under 15 years of age were most affected. Nucleotide sequencing of six OROV isolates identified that genotype II was associated with the human disease epidemic.

Conclusions: Oropouche fever, which has re-emerged in the Bragantina region in eastern Amazon 26 years after the last epidemic, is caused by genotype II, a lineage previously found only in Peru and western Brazil.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources