TGF-beta signaling in vascular biology and dysfunction
- PMID: 19114994
- DOI: 10.1038/cr.2008.326
TGF-beta signaling in vascular biology and dysfunction
Abstract
Transforming growth factor (TGF)-beta family members are multifunctional cytokines that elicit their effects on cells, including endothelial and mural cells, via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. Knock-out mouse models for TGF-beta family signaling pathway components have revealed their critical importance in proper yolk sac angiogenesis. Genetic studies in humans have linked mutations in these signaling components to specific cardiovascular syndromes such as hereditary hemorrhagic telangiectasia, primary pulmonary hypertension and Marfan syndrome. In this review, we present recent advances in our understanding of the role of TGF-beta receptor signaling in vascular biology and disease, and discuss how this may be applied for therapy.
Similar articles
-
The role of Smad signaling in vascular and hematopoietic development revealed by studies using genetic mouse models.Sci China Life Sci. 2010 Apr;53(4):485-9. doi: 10.1007/s11427-010-0087-3. Epub 2010 May 7. Sci China Life Sci. 2010. PMID: 20596915 Review.
-
Divergence and convergence of TGF-beta/BMP signaling.J Cell Physiol. 2001 Jun;187(3):265-76. doi: 10.1002/jcp.1080. J Cell Physiol. 2001. PMID: 11319750 Review.
-
TGF-beta receptor function in the endothelium.Cardiovasc Res. 2005 Feb 15;65(3):599-608. doi: 10.1016/j.cardiores.2004.10.036. Cardiovasc Res. 2005. PMID: 15664386 Review.
-
BMP signaling in vascular diseases.FEBS Lett. 2012 Jul 4;586(14):1993-2002. doi: 10.1016/j.febslet.2012.04.030. Epub 2012 May 3. FEBS Lett. 2012. PMID: 22710160 Review.
-
[Signaling pathways of transforming growth factor beta family members].Postepy Biochem. 2006;52(4):360-6. Postepy Biochem. 2006. PMID: 17536504 Review. Polish.
Cited by
-
Identification of biomarkers, pathways and potential therapeutic agents for salt-sensitive hypertension using RNA-seq.Front Cardiovasc Med. 2022 Aug 10;9:963744. doi: 10.3389/fcvm.2022.963744. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36035920 Free PMC article.
-
From glioblastoma to endothelial cells through extracellular vesicles: messages for angiogenesis.Tumour Biol. 2016 Sep;37(9):12743-12753. doi: 10.1007/s13277-016-5165-0. Epub 2016 Jul 22. Tumour Biol. 2016. PMID: 27448307
-
The Role of Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic Nephropathy.Biomed Res Int. 2021 Apr 28;2021:6651075. doi: 10.1155/2021/6651075. eCollection 2021. Biomed Res Int. 2021. PMID: 33997036 Free PMC article. Review.
-
Aortic dissection and stroke in a 37-year-old woman: discovering an emerging heritable connective tissue disorder.Intern Emerg Med. 2015 Mar;10(2):165-70. doi: 10.1007/s11739-015-1187-7. Epub 2015 Jan 15. Intern Emerg Med. 2015. PMID: 25589165 No abstract available.
-
Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells.EMBO J. 2012 Oct 3;31(19):3885-900. doi: 10.1038/emboj.2012.246. Epub 2012 Aug 31. EMBO J. 2012. PMID: 22940691 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
