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Review
. 2009 Feb;9(2):83-9.
doi: 10.1038/nri2474.

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Jochen Huehn  1 , Julia K Polansky, Alf Hamann
Affiliations
Free article
Review

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Jochen Huehn et al. Nat Rev Immunol. 2009 Feb.
Free article

Abstract

Regulatory T (T(Reg)) cells constitute a unique T-cell lineage that has a crucial role in immunological tolerance. Several years ago, forkhead box P3 (FOXP3) was identified as the transcription factor that was responsible for determining the development and function of these cells. However, the underlying mechanisms that are involved in the regulation of the FOXP3 gene remain unclear and therefore preclude accurate identification and manipulation of T(Reg) cells. In this Progress article, we summarize recent advances in understanding how FOXP3 expression is controlled and highlight evidence suggesting that epigenetic regulation of the FOXP3 locus contributes to its role as a lineage-specification factor.

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References

    1. Blood. 2008 Sep 1;112(5):1813-21 - PubMed
    1. Nat Immunol. 2003 Apr;4(4):330-6 - PubMed
    1. Immunol Rev. 2006 Aug;212:99-113 - PubMed
    1. Blood. 2008 Sep 15;112(6):2340-52 - PubMed
    1. Blood. 2007 Oct 15;110(8):2983-90 - PubMed

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