Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008:45 Suppl 1:13-24.
doi: 10.1080/02770900802569942.

Pharmacokinetics and pharmacodynamics of inhaled glucocorticoids

Jennifer Padden  1 , David Skoner, Gunther Hochhaus
Affiliations

Pharmacokinetics and pharmacodynamics of inhaled glucocorticoids

Jennifer Padden et al. J Asthma. 2008.

Abstract

Inhaled corticosteroids are used widely to treat asthma. A number of different steroids and inhalation devices are available. The pharmacokinetic and pharmacodynamic properties of the different inhaled corticosteroids may influence their efficacy and safety profiles. Properties of an ideal inhaled corticosteroid include low oropharyngeal deposition, low oral bioavailability, high lung deposition, long pulmonary residence times, high receptor affinity, high plasma protein binding, and efficient systemic clearance. Attention to these parameters might help clinicians optimally balance between the safety and efficacy of inhaled corticosteroids in treating individual patients with asthma.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection.
    Sou T, Kukavica-Ibrulj I, Soukarieh F, Halliday N, Levesque RC, Williams P, Stocks M, Cámara M, Friberg LE, Bergström CAS. Sou T, et al. J Pharm Sci. 2019 Jan;108(1):630-640. doi: 10.1016/j.xphs.2018.09.017. Epub 2018 Sep 23. J Pharm Sci. 2019. PMID: 30257195 Free PMC article.
  • Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases.
    Duse M, Santamaria F, Verga MC, Bergamini M, Simeone G, Leonardi L, Tezza G, Bianchi A, Capuano A, Cardinale F, Cerimoniale G, Landi M, Malventano M, Tosca M, Varricchio A, Zicari AM, Alfaro C, Barberi S, Becherucci P, Bernardini R, Biasci P, Caffarelli C, Caldarelli V, Capristo C, Castronuovo S, Chiappini E, Cutrera R, De Castro G, De Franciscis L, Decimo F, Iacono ID, Diaferio L, Di Cicco ME, Di Mauro C, Di Mauro C, Di Mauro D, Di Mauro F, Di Mauro G, Doria M, Falsaperla R, Ferraro V, Fanos V, Galli E, Ghiglioni DG, Indinnimeo L, Kantar A, Lamborghini A, Licari A, Lubrano R, Luciani S, Macrì F, Marseglia G, Martelli AG, Masini L, Midulla F, Minasi D, Miniello VL, Del Giudice MM, Morandini SR, Nardini G, Nocerino A, Novembre E, Pajno GB, Paravati F, Piacentini G, Piersantelli C, Pozzobon G, Ricci G, Spanevello V, Turra R, Zanconato S, Borrelli M, Villani A, Corsello G, Di Mauro G, Peroni D. Duse M, et al. Ital J Pediatr. 2021 Apr 21;47(1):97. doi: 10.1186/s13052-021-01013-8. Ital J Pediatr. 2021. PMID: 33882987 Free PMC article.
  • Benefit:Risk Profile of Budesonide in Obstructive Airways Disease.
    Tashkin DP, Lipworth B, Brattsand R. Tashkin DP, et al. Drugs. 2019 Nov;79(16):1757-1775. doi: 10.1007/s40265-019-01198-7. Drugs. 2019. PMID: 31549299 Free PMC article. Review.
  • Exploring the influence of the microbiome on the pharmacology of anti-asthmatic drugs.
    Chan M, Ghadieh C, Irfan I, Khair E, Padilla N, Rebeiro S, Sidgreaves A, Patravale V, Disouza J, Catanzariti R, Pont L, Williams K, De Rubis G, Mehndiratta S, Dhanasekaran M, Dua K. Chan M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Feb;397(2):751-762. doi: 10.1007/s00210-023-02681-5. Epub 2023 Aug 31. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37650889 Free PMC article. Review.

Substances

LinkOut - more resources