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. 2008 Dec;71(12):2068-72.
doi: 10.1021/np800509u.

Triprenylated flavonoids from Dorstenia psilurus and their alpha-glucosidase inhibition properties

Turibio K Tabopda  1 , Joseph Ngoupayo, Patrice K Awoussong, Anne-Claire Mitaine-Offer, Muhammad S Ali, Bonaventure T Ngadjui, Marie-Aleth Lacaille-Dubois
Affiliations

Triprenylated flavonoids from Dorstenia psilurus and their alpha-glucosidase inhibition properties

Turibio K Tabopda et al. J Nat Prod. 2008 Dec.

Abstract

Six new unusual C-4'-prenylated flavonols, dorsilurins F-K (1-6), together with six known compounds were isolated from the roots of Dorstenia psilurus, and their structures were elucidated on the basis of spectroscopic evidence. The isolated compounds exhibited moderate to low alpha-glucosidase inhibitory activity. Dorsilurin F (1), with three unmodified prenyl groups, was the most active, while dorsilurin K (6), with only one unmodified prenyl group, was the least active compound. Furthermore, NMR data of dorsilurin C (7), isolated some years ago from the same plant, have been revised.

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