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Review
. 2008 Dec;8(12):751-62.
doi: 10.1016/S1473-3099(08)70279-2.

Current control and treatment of multidrug-resistant Acinetobacter baumannii infections

Drosos E Karageorgopoulos  1 , Matthew E Falagas
Affiliations
Review

Current control and treatment of multidrug-resistant Acinetobacter baumannii infections

Drosos E Karageorgopoulos et al. Lancet Infect Dis. 2008 Dec.

Abstract

Institutional outbreaks caused by Acinetobacter baumannii strains that have acquired multiple mechanisms of antimicrobial drug resistance constitute a growing public-health problem. Because of complex epidemiology, infection control of these outbreaks is difficult to attain. Identification of potential common sources of an outbreak, through surveillance cultures and epidemiological typing studies, can aid in the implementation of specific control measures. Adherence to a series of infection control methods including strict environmental cleaning, effective sterilisation of reusable medical equipment, attention to proper hand hygiene practices, and use of contact precautions, together with appropriate administrative guidance and support, are required for the containment of an outbreak. Effective antibiotic treatment of A baumannii infections, such as ventilator-associated pneumonia and bloodstream infections, is also of paramount importance. Carbapenems have long been regarded as the agents of choice, but resistance rates have risen substantially in some areas. Sulbactam has been successfully used in the treatment of serious A baumannii infections; however, the activity of this agent against carbapenem-resistant isolates is decreasing. Polymyxins show reliable antimicrobial activity against A baumannii isolates. Available clinical reports, although consisting of small-sized studies, support their effectiveness and mitigate previous concerns for toxicity. Minocycline, and particularly its derivative, tigecycline, have shown high antimicrobial activity against A baumannii, though relevant clinical evidence is still scarce. Several issues regarding the optimum therapeutic choices for multidrug-resistant A baumannii infections need to be clarified by future research.

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Comment in

  • Acinetobacter baumannii infections in children.
    de Benedictis FM, Osimani P, Gabriele C. de Benedictis FM, et al. Lancet Infect Dis. 2010 Mar;10(3):143-4. doi: 10.1016/S1473-3099(10)70030-X. Lancet Infect Dis. 2010. PMID: 20185091 No abstract available.

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