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. 2007;2(6):931-938.
doi: 10.1586/17469899.2.6.931.

Matrix Metalloproteinases as Mediators of Primary and Secondary Cataracts

Judith A West-Mays  1 , Giuseppe Pino
Affiliations

Matrix Metalloproteinases as Mediators of Primary and Secondary Cataracts

Judith A West-Mays et al. Expert Rev Ophthalmol. 2007.

Abstract

The matrix metalloproteinases (MMPs) are a family of endopeptidases involved in numerous remodeling and fibrotic disorders. Although MMPs have been shown to play important roles in regenerative and disease processes in many parts of the eye, including the cornea, retina and trabecular meshwork, the role of MMPs in the normal and cataractous lens has only recently been studied. These investigations have shown that multiple MMPs are expressed in the lens and their expression is altered in a number of cataract phenotypes. However, anterior subcapsular cataract and posterior capsular opacification, cataracts of a fibrotic nature, show a particular involvement of MMPs. This review will highlight recent findings that suggest a causative role for MMPs in these fibrotic cataract phenotypes.

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References

    1. WHO Ageing: a public health challenge. In: Fact sheet N°135. 1998.
    1. WHO Blindness: Vision 2020 – The Global Initiative for the Elimination of Avoidable Blindness. In: Fact sheet N°213. 2000.
    1. Allen D. Cataract surgery. Expert Rev. Ophthalmol. 2007;2(2):213–225.
    1. Babizhayev MA, Deyev AI, Yermakova VN, Brikman IV, Bours J. Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes. Drugs R D. 2004;5(3):125–139. - PubMed
    1. Bullimore MA, Bailey IL. Foreward: Clarifying Cataract. Optom. Vis. Sci. 1993;70:867–868. - PubMed

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