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. 2009 Jan;36(1):116-9.
doi: 10.3899/jrheum.080664.

Limited utility of rapamycin in severe, refractory Wegener's granulomatosis

Curry L Koening  1 , José Hernández-Rodríguez, Eamonn S Molloy, Tiffany M Clark, Gary S Hoffman
Affiliations

Limited utility of rapamycin in severe, refractory Wegener's granulomatosis

Curry L Koening et al. J Rheumatol. 2009 Jan.

Abstract

Objective: We report our experience using rapamycin in patients with Wegener's granulomatosis (WG) who failed to achieve remission with conventional treatment.

Methods: Eight patients received rapamycin for severe, refractory WG. Clinical outcomes were reviewed retrospectively.

Results: Four patients treated with rapamycin sustained remissions of at least 6 months' duration while receiving prednisone<or=10 mg/day; 2 relapsed during followup. Five patients discontinued rapamycin due to continued disease activity, cancer, or adverse events.

Conclusion: Toxicities due to rapamycin were numerous; consistent proof of efficacy in this pilot experience with WG was not seen.

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