BAG-1 induces autophagy for cardiac cell survival
- PMID: 19001866
- DOI: 10.4161/auto.5.1.7303
BAG-1 induces autophagy for cardiac cell survival
Abstract
The Bcl-2 associated athanogene (BAG) family of proteins function as cochaperones by bridging molecules that recruit molecular chaperones to target proteins. BAG-1 provides a physical link between the heat shock proteins Hsc70/Hsp70 and the proteasome to facilitate ubiquitin-proteasome-mediated protein degradation. In addition to the proteasome, protein degradation via autophagy is responsible for maintaining cellular metabolism, organelle homeostasis and redox equilibrium. Our recent report shows that autophagy plays an important role in cardiac adaptation-induced cell survival against ischemia-reperfusion injury in association with the BAG-1 protein. BAG-1 is associated with the autophagosomal membrane protein LC3-II and it may participate in the induction of autophagy via Hsc70. Moreover, another BAG family member, BAG-3, is responsible for the induction of macroautophagy in association with HspB8. These results show the involvement of BAG family members in the induction of autophagy for the degradation of damaged or oxidized proteins to promote cell survival.
Similar articles
-
BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome.J Biol Chem. 2004 May 14;279(20):20723-8. doi: 10.1074/jbc.M400399200. Epub 2004 Feb 20. J Biol Chem. 2004. PMID: 14978028
-
Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein.J Cell Mol Med. 2009 Feb;13(2):373-87. doi: 10.1111/j.1582-4934.2008.00495.x. Epub 2008 Sep 13. J Cell Mol Med. 2009. PMID: 18793351 Free PMC article.
-
BAG3 and friends: co-chaperones in selective autophagy during aging and disease.Autophagy. 2011 Jul;7(7):795-8. doi: 10.4161/auto.7.7.15844. Autophagy. 2011. PMID: 21681022
-
BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions.Cell Stress Chaperones. 2003 Fall;8(3):225-31. doi: 10.1379/1466-1268(2003)008<0225:bnefoh>2.0.co;2. Cell Stress Chaperones. 2003. PMID: 14984055 Free PMC article. Review.
-
What's in the 'BAG'?--A functional domain analysis of the BAG-family proteins.Cancer Lett. 2002 Dec 15;188(1-2):25-32. doi: 10.1016/s0304-3835(02)00456-1. Cancer Lett. 2002. PMID: 12406544 Review.
Cited by
-
The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective.Cardiovasc Res. 2010 Jan 15;85(2):253-62. doi: 10.1093/cvr/cvp287. Epub 2009 Aug 20. Cardiovasc Res. 2010. PMID: 19696071 Free PMC article. Review.
-
Untangling the Roles of Anti-Apoptosis in Regulating Programmed Cell Death using Humanized Yeast Cells.Front Oncol. 2012 Jun 13;2:59. doi: 10.3389/fonc.2012.00059. eCollection 2012. Front Oncol. 2012. PMID: 22708116 Free PMC article.
-
Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.Autophagy. 2019 Dec;15(12):2142-2162. doi: 10.1080/15548627.2019.1615822. Epub 2019 May 22. Autophagy. 2019. PMID: 31066324 Free PMC article.
-
Identification of an 11-Autophagy-Related-Gene Signature as Promising Prognostic Biomarker for Bladder Cancer Patients.Biology (Basel). 2021 Apr 27;10(5):375. doi: 10.3390/biology10050375. Biology (Basel). 2021. PMID: 33925460 Free PMC article.
-
Autophagy during cardiac stress: joys and frustrations of autophagy.Annu Rev Physiol. 2010;72:45-59. doi: 10.1146/annurev-physiol-021909-135757. Annu Rev Physiol. 2010. PMID: 20148666 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
