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Review
. 2009 May;35(3):318-26.
doi: 10.1016/j.burns.2008.08.002. Epub 2008 Oct 31.

Gammadelta T-cells: potential regulators of the post-burn inflammatory response

Martin G Schwacha  1
Affiliations
Review

Gammadelta T-cells: potential regulators of the post-burn inflammatory response

Martin G Schwacha. Burns. 2009 May.

Abstract

Severe burn induces an immunopathological response that contributes to the development of a systemic inflammatory response (SIRS) and subsequent multiple organ failure. While, multiple immune cells type (T-cells, macrophages, neutrophils) are involved in this response, recent evidence suggests that a unique T-cell subset, gammadelta T-cells are central in the response to injury. While gammadelta T-cells represent only a small percentage of the total T-cell population, they display specific functional characteristics that uniquely position them in the immune/inflammatory axis to influence a number of important aspects of the body's response to burn. This review will focus on the potential regulator role of gammadelta T-cells in immunopathological response following burn and thereby their potential as therapeutic targets for affecting inflammation and healing.

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Figures

Figure 1
Figure 1
Stages of wound healing. Wound healing involves a number of overlapping phases over a period of months that include: hemostasis, inflammation, proliferation and resolution.
Figure 2
Figure 2
Immune cell content of the healing wound. The cellular components of the immune system in the wound in a specific sequence and time frame.
Figure 3
Figure 3
Schematic of the proposed role of γδ T-cells in wound healing. Under normal conditions γδ T-cells are recruited to the dermal wound from surrounding skin and the blood. Burn injury (flame graphics) suppresses this response at multiple steps. See text for details.
See this image and copyright information in PMC

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References

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