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. 2008 Sep 11;3(3):301-13.
doi: 10.1016/j.stem.2008.07.003.

A perivascular origin for mesenchymal stem cells in multiple human organs

Mihaela Crisan  1 , Solomon Yap, Louis Casteilla, Chien-Wen Chen, Mirko Corselli, Tea Soon Park, Gabriella Andriolo, Bin Sun, Bo Zheng, Li Zhang, Cyrille Norotte, Pang-Ning Teng, Jeremy Traas, Rebecca Schugar, Bridget M Deasy, Stephen Badylak, Hans-Jörg Buhring, Jean-Paul Giacobino, Lorenza Lazzari, Johnny Huard, Bruno Péault
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Free article

A perivascular origin for mesenchymal stem cells in multiple human organs

Mihaela Crisan et al. Cell Stem Cell. .
Free article

Abstract

Mesenchymal stem cells (MSCs), the archetypal multipotent progenitor cells derived in cultures of developed organs, are of unknown identity and native distribution. We have prospectively identified perivascular cells, principally pericytes, in multiple human organs including skeletal muscle, pancreas, adipose tissue, and placenta, on CD146, NG2, and PDGF-Rbeta expression and absence of hematopoietic, endothelial, and myogenic cell markers. Perivascular cells purified from skeletal muscle or nonmuscle tissues were myogenic in culture and in vivo. Irrespective of their tissue origin, long-term cultured perivascular cells retained myogenicity; exhibited at the clonal level osteogenic, chondrogenic, and adipogenic potentials; expressed MSC markers; and migrated in a culture model of chemotaxis. Expression of MSC markers was also detected at the surface of native, noncultured perivascular cells. Thus, blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.

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  • All MSCs are pericytes?
    Caplan AI. Caplan AI. Cell Stem Cell. 2008 Sep 11;3(3):229-30. doi: 10.1016/j.stem.2008.08.008. Cell Stem Cell. 2008. PMID: 18786406 No abstract available.

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