Pathological autoantibodies in cardiomyopathy
- PMID: 18781471
- DOI: 10.1080/08916930802031603
Pathological autoantibodies in cardiomyopathy
Abstract
Myocardial dilatation and dysfunction in the absence of significant coronary heart disease has been termed "idiopathic" dilated cardiomyopathy (iDCM), which--according to the 1995 task force report on the classification of cardiomyopathies-besides genetic, toxic or infectious causes also includes immune-mediated heart muscle damage in the spectrum of putative DCM etiologies. Incremental research on this topic particularly in the past few years has significantly contributed evidence to the hypothesis that autoimmune reactions against certain myocyte antigens may play a pivotal role in the initiation and/or progression of DCM. Recent transfer experiments in animals (mostly rodents) performed by various groups throughout the world and some preliminary clinical data even indicate that a few of these autoantibodies are indeed "pathogenic", inferring that they can actually cause cardiac dysfunction and heart failure by their own. Dependent on the individual genetic predisposition such harmful autoimmune reactions are supposed to emerge as a consequence of heart muscle damage induced by viral triggers, ischemia or exposure to cardiotoxins leading to myocyte apoptosis (and/or necrosis) and subsequent liberation of a "critical amount" of self-antigens previously hidden to the immune system. The following article will summarize the so far available evidence for an implication of a confined number of harmful autoantibodies directed against specific cardiac antigens in the pathogenesis of DCM.
Similar articles
-
Inflammatory dilated cardiomyopathy (DCMI).Herz. 2005 Sep;30(6):535-44. doi: 10.1007/s00059-005-2730-5. Herz. 2005. PMID: 16170686 Review.
-
Clinical implications of anti-heart autoantibodies in myocarditis and dilated cardiomyopathy.Autoimmunity. 2008 Feb;41(1):35-45. doi: 10.1080/08916930701619235. Autoimmunity. 2008. PMID: 18176863 Review.
-
Anti-heart autoantibodies in familial dilated cardiomyopathy.Autoimmunity. 2008 Sep;41(6):462-9. doi: 10.1080/08916930802031546. Autoimmunity. 2008. PMID: 18781472 Review.
-
[Idiopathic dilated cardiomyopathy: a persistent viral infection or an organ-specific autoimmune disease? The trial of 2 major pathogenetic hypotheses].G Ital Cardiol. 1992 Jan;22(1):63-72. G Ital Cardiol. 1992. PMID: 1624070 Review. Italian.
-
Beta 1-adrenergic receptor-directed autoimmunity as a cause of dilated cardiomyopathy in rats.Int J Cardiol. 2006 Sep 10;112(1):7-14. doi: 10.1016/j.ijcard.2006.05.008. Epub 2006 Jul 26. Int J Cardiol. 2006. PMID: 16872696 Review.
Cited by
-
Vascular dysfunction in idiopathic dilated cardiomyopathy.Nat Rev Cardiol. 2009 Sep;6(9):590-8. doi: 10.1038/nrcardio.2009.130. Epub 2009 Jul 28. Nat Rev Cardiol. 2009. PMID: 19636323 Review.
-
B Cell in Autoimmune Diseases.Scientifica (Cairo). 2012;2012:215308. doi: 10.6064/2012/215308. Scientifica (Cairo). 2012. PMID: 23807906 Free PMC article.
-
Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength.Int J Mol Sci. 2020 Jan 11;21(2):463. doi: 10.3390/ijms21020463. Int J Mol Sci. 2020. PMID: 31940750 Free PMC article. Clinical Trial.
-
Plasma exchange for the patients with dilated cardiomyopathy in children is safe and effective in improving both cardiac function and daily activities.J Artif Organs. 2017 Sep;20(3):236-243. doi: 10.1007/s10047-017-0956-7. Epub 2017 Apr 5. J Artif Organs. 2017. PMID: 28382424
-
The clinical and diagnostic significance of anti-myosin autoantibodies in cardiac disease.Clin Rev Allergy Immunol. 2013 Feb;44(1):98-108. doi: 10.1007/s12016-010-8229-8. Clin Rev Allergy Immunol. 2013. PMID: 21207194 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
