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. 2009 Mar;135(3):439-49.
doi: 10.1007/s00432-008-0469-0. Epub 2008 Sep 10.

Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection

Yi-Wei Li  1 , Shuang-Jian Qiu, Jia Fan, Qiang Gao, Jian Zhou, Yong-Sheng Xiao, Yang Xu, Xiao-Ying Wang, Jian Sun, Xiao-Wu Huang
Affiliations

Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection

Yi-Wei Li et al. J Cancer Res Clin Oncol. 2009 Mar.

Abstract

Purpose: To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (T(M)), in hepatocellular carcinoma (HCC) patients following resection.

Methods: The infiltration of TAM and T(M) was assessed by immunohistochemistry in tissue microarray containing 302 HCC specimens. Correlations between TAM/T(M) infiltration and clinicopathologic features, disease-free survival (DFS) and overall survival (OS) were statistically analyzed.

Results: High TAM infiltration was associated with both improved DFS (P = 0.0021) and OS (P = 0.0481). Multivariate analysis identified TAM infiltration as independent prognostic factor for DFS (P = 0.004) and OS (P = 0.049). A second analysis clarified the synergistic effect of TAM&T(M) infiltration for DFS (P = 0.004) and OS (P = 0.040).

Conclusions: Both TAM infiltration alone and concomitant infiltration of TAM&T(M) are associated with improved DFS/OS, suggesting that TAM could protect HCC patients from recurrence/metastasis and prolong survival by distinct mechanisms.

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References

    1. Clin Cancer Res. 2007 Oct 1;13(19):5784-9 - PubMed
    1. Clin Immunol. 2002 Mar;102(3):291-301 - PubMed
    1. Annu Rev Immunol. 1997;15:323-50 - PubMed
    1. Eur J Cancer. 2006 Apr;42(6):717-27 - PubMed
    1. Science. 2006 Sep 29;313(5795):1960-4 - PubMed

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