PTEN at the crossroad of metabolic diseases and cancer in the liver
- PMID: 18772845
PTEN at the crossroad of metabolic diseases and cancer in the liver
Abstract
The tumor suppressor PTEN is a phosphoinositide phosphatase regulating the PI3K/Akt signaling pathways and mutated or deleted in a variety of human cancers. Recent evidence indicates that dysregulated PTEN expression and activity in the liver critically affect hepatic insulin sensitivity and trigger the development of non-alcoholic fatty liver diseases. As well, PTEN expression/activity is also affected with HBV and HCV infection, or following alcohol-related injury. Finally, PTEN mutations/deletions or low PTEN expression are associated with diverse liver malignancies thus suggesting a critical role for PTEN in hepatic cancers. This review will focus on our current knowledge of the regulation of PTEN expression/activity and the role of this phosphatase in liver diseases.
Similar articles
-
PTEN in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and cancer.Dig Dis. 2010;28(1):236-46. doi: 10.1159/000282095. Epub 2010 May 7. Dig Dis. 2010. PMID: 20460918 Review.
-
PTEN in liver diseases and cancer.World J Gastroenterol. 2010 Oct 7;16(37):4627-33. doi: 10.3748/wjg.v16.i37.4627. World J Gastroenterol. 2010. PMID: 20872961 Free PMC article.
-
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα).J Biol Chem. 2013 Aug 30;288(35):25007-25024. doi: 10.1074/jbc.M113.450353. Epub 2013 Jul 8. J Biol Chem. 2013. PMID: 23836899 Free PMC article.
-
PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway.Oncol Rep. 2010 Jun;23(6):1593-600. doi: 10.3892/or_00000800. Oncol Rep. 2010. PMID: 20428814
-
PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy.Mol Cancer. 2018 Feb 19;17(1):37. doi: 10.1186/s12943-018-0803-3. Mol Cancer. 2018. PMID: 29455665 Free PMC article. Review.
Cited by
-
Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway.Cancer Biol Ther. 2014 May;15(5):524-32. doi: 10.4161/cbt.28018. Epub 2014 Feb 12. Cancer Biol Ther. 2014. PMID: 24521981 Free PMC article.
-
Association of PTEN gene polymorphisms with liver cancer risk.Int J Clin Exp Pathol. 2015 Nov 1;8(11):15198-203. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 26823866 Free PMC article.
-
PTEN-related risk classification models for predicting prognosis and immunotherapy response of hepatocellular carcinoma.Discov Oncol. 2023 Jul 20;14(1):134. doi: 10.1007/s12672-023-00743-x. Discov Oncol. 2023. PMID: 37470852 Free PMC article.
-
A global analysis on the differential regulation of RNA binding proteins (RBPs) by TNF-α as potential modulators of metabolic syndromes.BBA Adv. 2021 Dec 29;2:100037. doi: 10.1016/j.bbadva.2021.100037. eCollection 2022. BBA Adv. 2021. PMID: 37082594 Free PMC article.
-
Inhibition of IRS-1 by hepatitis C virus infection leads to insulin resistance in a PTEN-dependent manner.Virol J. 2015 Feb 3;12:12. doi: 10.1186/s12985-015-0241-4. Virol J. 2015. PMID: 25645159 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
