doi: 10.1099/0022-1317-33-3-471.
The effects of herpes simplex virus type 1 on cellular DNA-dependent RNA polymerase activities
- PMID: 187722
- DOI: 10.1099/0022-1317-33-3-471
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The effects of herpes simplex virus type 1 on cellular DNA-dependent RNA polymerase activities
J Gen Virol.
1976 Dec.
Abstract
An investigation of the activity of nuclear RNA polymerase following infection of LS cells with HSV-1 shows a decline in both major activities. This effect is not entirely due to inhibition of cellular protein synthesis, and the effect of alpha-amanitin-sensitive RNA polymerase is mediated by a protein(s) synthesized in the infected cell. Changes in the properties of this RNA polymerase activity include a reduction in the relative UTP/GTP incorporation ratio and an increased sensitivity to inhibition by actinomycin D, indicating that RNA polymerase II is involved in virus transcription.
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