Review
doi: 10.1038/nrn2477.
Epub 2008 Sep 4.
Research in motion: the enigma of Parkinson's disease pathology spread
Affiliations
- PMID: 18769444
- DOI: 10.1038/nrn2477
Item in Clipboard
Review
Research in motion: the enigma of Parkinson's disease pathology spread
Nat Rev Neurosci.
2008 Oct.
Abstract
Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.
Similar articles
-
Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.Brain. 2005 Nov;128(Pt 11):2654-64. doi: 10.1093/brain/awh584. Epub 2005 Jul 6. Brain. 2005. PMID: 16000336
-
The progression of pathology in Parkinson's disease.Ann N Y Acad Sci. 2010 Jan;1184:188-95. doi: 10.1111/j.1749-6632.2009.05118.x. Ann N Y Acad Sci. 2010. PMID: 20146698 Review.
-
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease.Mov Disord. 2010 Jun 15;25(8):1091-6. doi: 10.1002/mds.23012. Mov Disord. 2010. PMID: 20198645
-
A comparison of degeneration in motor thalamus and cortex between progressive supranuclear palsy and Parkinson's disease.Brain. 2005 Oct;128(Pt 10):2272-80. doi: 10.1093/brain/awh596. Epub 2005 Jul 13. Brain. 2005. PMID: 16014651
-
Controversy: is Parkinson's disease a single disease entity? Yes.Parkinsonism Relat Disord. 2005 Jun;11 Suppl 1:S31-7. doi: 10.1016/j.parkreldis.2005.02.011. Epub 2005 Apr 20. Parkinsonism Relat Disord. 2005. PMID: 15885626 Review.
Cited by
-
Anterograde degeneration along the visual pathway after optic nerve injury.PLoS One. 2012;7(12):e52061. doi: 10.1371/journal.pone.0052061. Epub 2012 Dec 26. PLoS One. 2012. PMID: 23300590 Free PMC article.
-
Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease.Front Neurosci. 2015 Mar 9;9:59. doi: 10.3389/fnins.2015.00059. eCollection 2015. Front Neurosci. 2015. PMID: 25805964 Free PMC article. Review.
-
Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.Acta Neuropathol. 2014 May;127(5):645-65. doi: 10.1007/s00401-014-1268-0. Acta Neuropathol. 2014. PMID: 24659240 Free PMC article.
-
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.Nat Commun. 2011 Aug 23;2:440. doi: 10.1038/ncomms1453. Nat Commun. 2011. PMID: 21863007 Free PMC article.
-
The cervical lymph node contributes to peripheral inflammation related to Parkinson's disease.J Neuroinflammation. 2023 Apr 10;20(1):93. doi: 10.1186/s12974-023-02770-5. J Neuroinflammation. 2023. PMID: 37038192 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
