Identification of Ets- and notch-related subunits in GA binding protein
- PMID: 1876836
- DOI: 10.1126/science.1876836
Identification of Ets- and notch-related subunits in GA binding protein
Abstract
Recombinant cDNA clones that encode two distinct subunits of the transcription factor GA binding protein (GABP) have been isolated. The predicted amino acid sequence of one subunit, GABP alpha, exhibits similarity to the sequence of the product of the ets-1 protooncogene in a region known to encompass the Ets DNA binding domain. The sequence of the second subunit, GABP beta, contains four 33-amino acid repeats located close to the NH2-terminus of the subunit. The sequences of these repeats are similar to repeats in several transmembrane proteins, including Notch from Drosophila melanogaster and Glp-1 and Lin-12 from Caenorhabditis elegans. Avid, sequence-specific binding to DNA required the presence of both polypeptides, revealing a conceptual convergence of nuclear transforming proteins and membrane-anchored proteins implicated in developmentally regulated signal transduction processes.
Comment in
-
New role found for a common protein "motif".Science. 1991 Aug 16;253(5021):742. doi: 10.1126/science.1831563. Science. 1991. PMID: 1831563 No abstract available.
Similar articles
-
Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex.Science. 1991 Aug 16;253(5021):762-8. doi: 10.1126/science.1876833. Science. 1991. PMID: 1876833
-
Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins.Genes Dev. 1992 Dec;6(12B):2502-12. doi: 10.1101/gad.6.12b.2502. Genes Dev. 1992. PMID: 1340465
-
Redox regulation of GA-binding protein-alpha DNA binding activity.J Biol Chem. 1996 Oct 11;271(41):25617-23. doi: 10.1074/jbc.271.41.25617. J Biol Chem. 1996. PMID: 8810337
-
GA-binding protein transcription factor: a review of GABP as an integrator of intracellular signaling and protein-protein interactions.Blood Cells Mol Dis. 2004 Jan-Feb;32(1):143-54. doi: 10.1016/j.bcmd.2003.09.005. Blood Cells Mol Dis. 2004. PMID: 14757430 Review.
-
Molecular analysis of the ets genes and their products.Crit Rev Oncog. 1990;1(4):409-36. Crit Rev Oncog. 1990. PMID: 1964597 Review.
Cited by
-
Functional analysis of transcription factor binding sites in human promoters.Genome Biol. 2012 Sep 26;13(9):R50. doi: 10.1186/gb-2012-13-9-r50. Genome Biol. 2012. PMID: 22951020 Free PMC article.
-
An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene.Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8889-93. doi: 10.1073/pnas.89.19.8889. Proc Natl Acad Sci U S A. 1992. PMID: 1409581 Free PMC article.
-
Participation of Ets transcription factors in the glucocorticoid response of the rat tyrosine aminotransferase gene.Mol Cell Biol. 1994 Jun;14(6):4116-25. doi: 10.1128/mcb.14.6.4116-4125.1994. Mol Cell Biol. 1994. PMID: 7910945 Free PMC article.
-
Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancer.Mol Cell Biol. 1994 Nov;14(11):7569-80. doi: 10.1128/mcb.14.11.7569-7580.1994. Mol Cell Biol. 1994. PMID: 7935472 Free PMC article.
-
Raf-1 kinase targets GA-binding protein in transcriptional regulation of the human immunodeficiency virus type 1 promoter.J Virol. 1996 Apr;70(4):2260-8. doi: 10.1128/JVI.70.4.2260-2268.1996. J Virol. 1996. PMID: 8642652 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
