Characterization of the major regulatory element upstream of the human alpha-globin gene cluster

doi:10.1128/mcb.11.9.4679-4689.1991

. 1991 Sep;11(9):4679-89.

doi: 10.1128/mcb.11.9.4679-4689.1991.

Characterization of the major regulatory element upstream of the human alpha-globin gene cluster

A P Jarman¹, W G Wood, J A Sharpe, G Gourdon, H Ayyub, D R Higgs

Affiliations

PMID: 1875946
PMCID: PMC361359
DOI: 10.1128/mcb.11.9.4679-4689.1991

Characterization of the major regulatory element upstream of the human alpha-globin gene cluster

A P Jarman et al. Mol Cell Biol. 1991 Sep.

. 1991 Sep;11(9):4679-89.

doi: 10.1128/mcb.11.9.4679-4689.1991.

Authors

A P Jarman¹, W G Wood, J A Sharpe, G Gourdon, H Ayyub, D R Higgs

Affiliation

¹ MRC Molecular Haematology Unit, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

PMID: 1875946
PMCID: PMC361359
DOI: 10.1128/mcb.11.9.4679-4689.1991

Abstract

The major positive regulatory activity of the human alpha-globin gene complex has been localized to an element associated with a strong erythroid-specific DNase I hypersensitive site (HS -40) located 40 kb upstream of the zeta 2-globin mRNA cap site. Footprint and gel shift analyses of the element have demonstrated the presence of four binding sites for the nuclear factor GATA-1 and two sites corresponding to the AP-1 consensus binding sequence. This region resembles one of the major elements of the beta-globin locus control region in its constitution and characteristics; this together with evidence from expression studies suggests that HS -40 is a primary element controlling alpha-globin gene expression.

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References

1. Genes Dev. 1990 Sep;4(9):1588-601 - PubMed
1. Proc Natl Acad Sci U S A. 1985 Oct;82(19):6384-8 - PubMed
1. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9431-5 - PubMed
1. Nucleic Acids Res. 1990 Oct 25;18(20):6011-7 - PubMed
1. Proc Natl Acad Sci U S A. 1989 Jan;86(1):37-41 - PubMed

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[1] Genes Dev. 1990 Sep;4(9):1588-601 - PubMed

[2] Genes Dev. 1990 Sep;4(9):1588-601 - PubMed

[3] Proc Natl Acad Sci U S A. 1985 Oct;82(19):6384-8 - PubMed

[4] Proc Natl Acad Sci U S A. 1985 Oct;82(19):6384-8 - PubMed

[5] Proc Natl Acad Sci U S A. 1990 Dec;87(23):9431-5 - PubMed

[6] Proc Natl Acad Sci U S A. 1990 Dec;87(23):9431-5 - PubMed

[7] Nucleic Acids Res. 1990 Oct 25;18(20):6011-7 - PubMed

[8] Nucleic Acids Res. 1990 Oct 25;18(20):6011-7 - PubMed

[9] Proc Natl Acad Sci U S A. 1989 Jan;86(1):37-41 - PubMed

[10] Proc Natl Acad Sci U S A. 1989 Jan;86(1):37-41 - PubMed

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Characterization of the major regulatory element upstream of the human alpha-globin gene cluster

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Characterization of the major regulatory element upstream of the human alpha-globin gene cluster

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