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Review
. 2008 Sep 1;68(17):6863-72.
doi: 10.1158/0008-5472.CAN-08-2852.

Advances in chemical carcinogenesis: a historical review and prospective

Lawrence A Loeb  1 , Curtis C Harris
Affiliations
Review

Advances in chemical carcinogenesis: a historical review and prospective

Lawrence A Loeb et al. Cancer Res. .
No abstract available

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Figures

Figure 1
Figure 1
Exposure of humans to chemical agents and the identification of the cancer-causing molecular species. NNK, 4-N-methyl-N-nitrosamino-1-(3pyridyl)-1-butanone; 4-ABP, 4-aminobiphenyl.
Figure 2
Figure 2
An overview of primary examples of events that have generated important insights into carcinogenesis.
Figure 2
Figure 2
An overview of primary examples of events that have generated important insights into carcinogenesis.
Figure 3
Figure 3
Mutations Result from Incomplete DNA Repair. DNA damage in cells results from environmental agents (carcinogens) and endogenous sources. Most damage is removed by DNA repair processes: BER, NER, or TCR. Misincorporated nucleotides are removed by mismatch repair. Lesions that are not repaired can stall DNA replication resulting in double-strand breaks and chromosomal rearrangements. Alternatively small adducts can be bypassed by family-Y DNA polymerases.
Figure 4
Figure 4
A modified molecular epidemiologic approach for validating causal relationships between carcinogen exposure and cancer risk.
See this image and copyright information in PMC

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