Review
doi: 10.1016/j.jns.2008.07.006.
Epub 2008 Aug 15.
B- and T-cell responses in multiple sclerosis: novel approaches offer new insights
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- PMID: 18707694
- DOI: 10.1016/j.jns.2008.07.006
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Review
B- and T-cell responses in multiple sclerosis: novel approaches offer new insights
J Neurol Sci.
.
Abstract
In experimental autoimmune encephalomyelitis (EAE), several target antigens of encephalitogenic T- and B-cell responses have been identified. However, in human multiple sclerosis (MS) the target antigens of pathogenic T and B cells have remained conjectural. Here we discuss how recent methodological advances have offered new insights into the nature of B- and T-cell receptor repertoires expressed in MS tissues, and how novel approaches have helped to identify neurofascin as a target of anti-axonal autoantibodies in MS and EAE.
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