Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets
- PMID: 18691096
- DOI: 10.2174/138161208784980617
Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets
Abstract
The inability of present therapies to mitigate the devastating effects of sepsis and multiple organ failure in the critically ill patient indicates that more knowledge of the pathophysiology of sepsis is needed if we are to develop better, more effective interventions. This review will examine the concept that a portion of the immune and organ dysfunctions encountered in the septic rodent/ patient is a reflection of not only the types of cells stimulating/ mediating the apoptotic response, but also the varying capacity of the target cell in a given tissue/ organ to perceive these death receptor stimuli as either an apoptotic, inflammatory and/or necrotic signal. We hope the discussion of such studies provides not only new insight into the pathobiology of sepsis, but also suggests possible therapeutic targets for the management of this devastating condition.
Similar articles
-
[New aspects of sepsis pathophysiology in critically ill].Vojnosanit Pregl. 2012 Jan;69(1):58-68. doi: 10.2298/vsp1201058d. Vojnosanit Pregl. 2012. PMID: 22397298 Review. Serbian. No abstract available.
-
Sepsis: links between pathogen sensing and organ damage.Curr Pharm Des. 2008;14(19):1840-52. doi: 10.2174/138161208784980572. Curr Pharm Des. 2008. PMID: 18691095 Free PMC article. Review.
-
Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: Novel therapeutic implications and challenges.Pharmacol Ther. 2017 Sep;177:56-66. doi: 10.1016/j.pharmthera.2017.02.040. Epub 2017 Feb 21. Pharmacol Ther. 2017. PMID: 28232275 Review.
-
A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome.Free Radic Biol Med. 2009 Dec 1;47(11):1517-25. doi: 10.1016/j.freeradbiomed.2009.08.019. Epub 2009 Aug 26. Free Radic Biol Med. 2009. PMID: 19715753 Review.
-
Multiple organ dysfunction syndrome: past, present and future.Surg Infect (Larchmt). 2000 Fall;1(3):155-61; discussion 161-3. doi: 10.1089/109629600750018088. Surg Infect (Larchmt). 2000. PMID: 12594886 Review.
Cited by
-
Improvement of the sepsis survival rate by adenosine 2a receptor antagonists depends on immune regulatory functions of regulatory T-cells.Front Immunol. 2022 Sep 6;13:996446. doi: 10.3389/fimmu.2022.996446. eCollection 2022. Front Immunol. 2022. PMID: 36148230 Free PMC article.
-
Effects of combination therapy with Shenfu Injection in critically ill patients with septic shock receiving mechanical ventilation: A multicentric, real-world study.Front Pharmacol. 2022 Nov 9;13:1041326. doi: 10.3389/fphar.2022.1041326. eCollection 2022. Front Pharmacol. 2022. PMID: 36438846 Free PMC article.
-
Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A Review.Front Cell Dev Biol. 2021 Jun 7;9:664896. doi: 10.3389/fcell.2021.664896. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34164394 Free PMC article. Review.
-
Xuebijing injection protects against sepsis-induced myocardial injury by regulating apoptosis and autophagy via mediation of PI3K/AKT/mTOR signaling pathway in rats.Aging (Albany NY). 2023 May 22;15(10):4374-4390. doi: 10.18632/aging.204740. Epub 2023 May 22. Aging (Albany NY). 2023. PMID: 37219401 Free PMC article.
-
Advances in the understanding and treatment of sepsis-induced immunosuppression.Nat Rev Nephrol. 2018 Feb;14(2):121-137. doi: 10.1038/nrneph.2017.165. Epub 2017 Dec 11. Nat Rev Nephrol. 2018. PMID: 29225343 Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical