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Comment
. 2008 Aug 12;105(32):11041-2.
doi: 10.1073/pnas.0805908105. Epub 2008 Aug 7.

PINK1 in mitochondrial function

Helene Plun-Favreau  1 , John Hardy
Affiliations
Comment

PINK1 in mitochondrial function

Helene Plun-Favreau et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The PD-associated kinase PINK1 is important for mitochondrial function. In response to cellular stress, PINK1 might regulate mitochondrial respiration and morphology. Whether the protein Parkin, which has also been associated with PD and acts downstream of PINK1, is important in these functional mechanisms remains to be confirmed. Although it is not yet proven, PINK1 could also participate in the degradation of misfolded proteins within the mitochondria through its interactions with chaperone molecules such as HtrA2, TRAP1, and HSP90.
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