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. 2009 Jan;88(1):150-61.
doi: 10.1002/jbm.b.31161.

Chitosan-NAC nanoparticles as a vehicle for nasal absorption enhancement of insulin

Xin Wang  1 , Chao Zheng, Zhongming Wu, Dayong Teng, Xinge Zhang, Zhen Wang, Chaoxing Li
Affiliations

Chitosan-NAC nanoparticles as a vehicle for nasal absorption enhancement of insulin

Xin Wang et al. J Biomed Mater Res B Appl Biomater. 2009 Jan.

Abstract

The purpose of this work was to investigate chitosan-N-acetyl-L-cysteine (chitosan-NAC) nanoparticles as a potential carrier system for the nasal delivery of insulin. For the study, we used insulin-loaded chitosan-NAC nanoparticles (140-210 nm in diameter) prepared by in situ gelation with tripolyphosphate (TPP), with positive zeta potential values of +19.5-31.7 mV and insulin loading capacities of 13-42%. The physicochemical properties of the nanoparticles were affected by the number of thiol groups present. Mucoadhesive properties, which were evaluated by measuring the in vitro absorbed mass of mucin, of chitosan-NAC nanoparticles were >1.8-fold that of unmodified chitosan nanoparticles. In aqueous solution, chitosan-NAC nanoparticles exhibited fast swelling behavior. Insulin was released from chitosan-NAC nanoparticles in vitro in an initial burst followed by slow release. Intranasal administration of chitosan-NAC nanoparticles in rats enhanced the absorption of insulin by the nasal mucosa compared with unmodified chitosan nanoparticles and control insulin solution. In light of these observations, the novel thiolated chitosan nanoparticles represent a promising vehicle for nasal insulin administration.

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