Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist

doi:10.1016/j.neuron.2008.06.014

Review

. 2008 Jul 10;59(1):8-10.

doi: 10.1016/j.neuron.2008.06.014.

Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist

Mathias Jucker¹, Frank L Heppner

Affiliations

Affiliation

¹ Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany. mathias.jucker@uni-tuebingen.de

PMID: 18614025
PMCID: PMC2676343
DOI: 10.1016/j.neuron.2008.06.014

Review

Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist

Mathias Jucker et al. Neuron. 2008.

. 2008 Jul 10;59(1):8-10.

doi: 10.1016/j.neuron.2008.06.014.

Authors

Mathias Jucker¹, Frank L Heppner

Affiliation

¹ Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany. mathias.jucker@uni-tuebingen.de

PMID: 18614025
PMCID: PMC2676343
DOI: 10.1016/j.neuron.2008.06.014

Abstract

In this month's issue of Nature Medicine, Town et al. suggest that peripheral macrophages invading the brain reduce cerebral amyloidosis and thus may play a key role in the pathogenesis of Alzheimer's disease (AD). This observation intensifies the longstanding controversy of whether mononuclear cells such as macrophages and/or microglial cells are beneficial or detrimental in AD.

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References

1. Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. Nat Neurosci. 2007;10:1538–1543. - PubMed
1. Asheuer M, Pflumio F, Benhamida S, Dubart-Kupperschmitt A, Fouquet F, Imai Y, Aubourg P, Cartier N. Proc Natl Acad Sci USA. 2004;101:3557–3562. - PMC - PubMed
1. Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, et al. Nat Med. 2000;6:916–919. - PubMed
1. Bulloch K, Miller MM, Gal-Toth J, Milner TA, Gottfried-Blackmore A, Waters EM, Kaunzner UW, Liu K, Lindquist R, Nussenzweig MC, et al. J Comp Neurol. 2008;508:687–710. - PubMed
1. El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD. Nat Med. 2007;13:432–438. - PubMed

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[1] Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. Nat Neurosci. 2007;10:1538–1543. - PubMed

[2] Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. Nat Neurosci. 2007;10:1538–1543. - PubMed

[3] Asheuer M, Pflumio F, Benhamida S, Dubart-Kupperschmitt A, Fouquet F, Imai Y, Aubourg P, Cartier N. Proc Natl Acad Sci USA. 2004;101:3557–3562. - PMC - PubMed

[4] Asheuer M, Pflumio F, Benhamida S, Dubart-Kupperschmitt A, Fouquet F, Imai Y, Aubourg P, Cartier N. Proc Natl Acad Sci USA. 2004;101:3557–3562. - PMC - PubMed

[5] Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, et al. Nat Med. 2000;6:916–919. - PubMed

[6] Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, et al. Nat Med. 2000;6:916–919. - PubMed

[7] Bulloch K, Miller MM, Gal-Toth J, Milner TA, Gottfried-Blackmore A, Waters EM, Kaunzner UW, Liu K, Lindquist R, Nussenzweig MC, et al. J Comp Neurol. 2008;508:687–710. - PubMed

[8] Bulloch K, Miller MM, Gal-Toth J, Milner TA, Gottfried-Blackmore A, Waters EM, Kaunzner UW, Liu K, Lindquist R, Nussenzweig MC, et al. J Comp Neurol. 2008;508:687–710. - PubMed

[9] El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD. Nat Med. 2007;13:432–438. - PubMed

[10] El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD. Nat Med. 2007;13:432–438. - PubMed

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Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist

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Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist

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