Secular decline in mortality from coronary heart disease in adults with diabetes mellitus: cohort study
- PMID: 18595902
- PMCID: PMC2453302
- DOI: 10.1136/bmj.39582.447998.BE
Secular decline in mortality from coronary heart disease in adults with diabetes mellitus: cohort study
Abstract
Objective: To examine trends in fatal coronary heart disease in adults with and without diabetes.
Design: Cohort study.
Setting: Two surveys of the Nord-Trøndelag health study (HUNT), a population based study in Norway.
Participants: 74 914 men and women from the first survey (1984-6) and 64 829 from the second survey (1995-7).
Main outcome measure: Age specific mortality from coronary heart disease among adults with and without diabetes during two consecutive nine year follow-up periods.
Results: A total of 2623 men and 1583 women died from coronary heart disease. Mortality rates were substantially lower during the most recent follow-up period: among men aged 70-79 without diabetes, deaths per 1000 person years declined from 16.38 to 8.79 (reduction 48%, 95% confidence interval 39% to 55%) and among women aged 70-79 from 6.84 to 2.68 (62%, 52% to 70%). Among the same age group with diabetes, deaths per 1000 person years in men declined from 38.97 to 17.89 (54%, 32% to 69%) and in women from 28.15 to 11.83 (59%, 37% to 73%). The reduction was more noticeable in age groups younger than 70 at baseline, and less pronounced among people aged 80 or more. Mortality from coronary heart disease was more than twofold higher in people with than without diabetes, with a slightly stronger association in women. The difference in mortality by diabetes status remained almost unchanged from the first to the second survey.
Conclusion: The strong general reduction in mortality rates from coronary heart disease from the first to the second follow-up period also benefited people with diabetes, but the more than twofold higher mortality from coronary heart disease associated with diabetes persisted over time.
Conflict of interest statement
Competing interests: None declared.
Similar articles
-
Diabetes mellitus and risk of fatal ischaemic heart disease by gender: 18 years follow-up of 74,914 individuals in the HUNT 1 Study.Eur Heart J. 2007 Dec;28(23):2924-9. doi: 10.1093/eurheartj/ehm447. Epub 2007 Oct 18. Eur Heart J. 2007. PMID: 17947212
-
Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies.BMJ. 2006 Jan 14;332(7533):73-8. doi: 10.1136/bmj.38678.389583.7C. Epub 2005 Dec 21. BMJ. 2006. PMID: 16371403 Free PMC article. Review.
-
Secular trends in all-cause and cause-specific mortality rates in people with diabetes in Hong Kong, 2001-2016: a retrospective cohort study.Diabetologia. 2020 Apr;63(4):757-766. doi: 10.1007/s00125-019-05074-7. Epub 2020 Jan 16. Diabetologia. 2020. PMID: 31942668
-
Diabetes and decline in heart disease mortality in US adults.JAMA. 1999 Apr 14;281(14):1291-7. doi: 10.1001/jama.281.14.1291. JAMA. 1999. PMID: 10208144
-
Explaining the sex difference in coronary heart disease mortality among patients with type 2 diabetes mellitus: a meta-analysis.Arch Intern Med. 2002 Aug 12-26;162(15):1737-45. doi: 10.1001/archinte.162.15.1737. Arch Intern Med. 2002. PMID: 12153377 Review.
Cited by
-
Type 2 diabetes: postprandial hyperglycemia and increased cardiovascular risk.Vasc Health Risk Manag. 2010 Mar 24;6:145-55. doi: 10.2147/vhrm.s8216. Vasc Health Risk Manag. 2010. PMID: 20448799 Free PMC article. Review.
-
Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials.Nat Rev Drug Discov. 2009 May;8(5):417-29. doi: 10.1038/nrd2476. Nat Rev Drug Discov. 2009. PMID: 19404313 Free PMC article. Review.
-
Similar decline in mortality rate of older persons with and without type 2 diabetes between 1993 and 2004 the Icelandic population-based Reykjavik and AGES-Reykjavik cohort studies.BMC Public Health. 2013 Jan 15;13:36. doi: 10.1186/1471-2458-13-36. BMC Public Health. 2013. PMID: 23320535 Free PMC article.
-
Differences in trends in estimated incidence of myocardial infarction in non-diabetic and diabetic people: Monitoring Trends and Determinants on Cardiovascular Diseases (MONICA)/Cooperative Health Research in the Region of Augsburg (KORA) registry.Diabetologia. 2009 Sep;52(9):1836-41. doi: 10.1007/s00125-009-1434-4. Epub 2009 Jul 15. Diabetologia. 2009. PMID: 19603150
-
The Predictive Role of Tooth Extractions, Oral Infections, and hs-C-Reactive Protein for Mortality in Individuals with and without Diabetes: A Prospective Cohort Study of a 12 1/2-Year Follow-Up.J Diabetes Res. 2017;2017:9590740. doi: 10.1155/2017/9590740. Epub 2017 Jun 21. J Diabetes Res. 2017. PMID: 28713837 Free PMC article.
References
-
- Reikvam A, Hagen TP. Markedly changed age distribution among patients hospitalized for acute myocardial infarction. Scand Cardiovasc J 2002;36:221-4. - PubMed
-
- Ergin A, Muntner P, Sherwin R, He J. Secular trends in cardiovascular disease mortality, incidence, and case fatality rates in adults in the United States. Am J Med 2004;117:219-27. - PubMed
-
- Rosamond WD, Chambless LE, Folsom AR, Cooper LS, Conwill DE, Clegg L, et al. Trends in the incidence of myocardial infarction and in mortality due to coronary heart disease, 1987 to 1994. N Engl J Med 1998;339:861-7. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources