Comment
doi: 10.1016/j.devcel.2008.05.012.
A silencing safeguard: links between RNA silencing and mRNA processing in Arabidopsis
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- PMID: 18539108
- PMCID: PMC2570776
- DOI: 10.1016/j.devcel.2008.05.012
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Comment
A silencing safeguard: links between RNA silencing and mRNA processing in Arabidopsis
Dev Cell.
2008 Jun.
Abstract
RNA silencing is a genome defense mechanism used by many eukaryotic organisms to fight viruses and to control transposable elements. Work by Gregory et al. on Arabidopsis thaliana (in this issue of Developmental Cell) revealed a mechanism whereby the plant protects its endogenous messenger RNAs from undergoing RNA silencing and uncovered an unexpected role of the cap-binding protein ABH1 in miRNA biogenesis.
Figures
Defects in cellular mRNA metabolism such as capping, splicing, and 3′ end cleavage and polyadenylation can result in uncapped mRNAs, mRNAs with introns retained, or mRNAs without polyA tails. These RNAs can be degraded by mRNA surveillance mechanisms involving 5′-3′ exonucleases such as EIN5/XRN4, 3′-5′ exonucleases such as the exosome, and nonsense-mediated decay. If the defective mRNAs are not properly removed, they can be channeled into the RNA silencing pathway through the activities of cellular RDR and Dicer.
Comment on
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A link between RNA metabolism and silencing affecting Arabidopsis development.Dev Cell. 2008 Jun;14(6):854-66. doi: 10.1016/j.devcel.2008.04.005. Epub 2008 May 22. Dev Cell. 2008. PMID: 18486559
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