Basophils enhance immunological memory responses
- PMID: 18516038
- DOI: 10.1038/ni.1621
Basophils enhance immunological memory responses
Abstract
The cellular basis of immunological memory remains a controversial issue. Here we show that basophils bound large amounts of intact antigens on their surface and were the main source of interleukins 6 and 4 in the spleen and bone marrow after restimulation with a soluble antigen. Depletion of basophils resulted in a much lower humoral memory response and greater susceptibility of immunized mice to sepsis induced by Streptococcus pneumoniae. Adoptive transfer of antigen-reactive basophils significantly increased specific antibody production, and activated basophils, together with CD4(+) T cells, profoundly enhanced B cell proliferation and immunoglobulin production. These basophil-dependent effects on B cells required interleukins 6 and 4 and increased the capacity of CD4(+) T cells to provide B cell help. Thus, basophils are important contributors to humoral memory immune responses.
Comment in
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Basophils now enhance memory.Nat Immunol. 2008 Jul;9(7):720-1. doi: 10.1038/ni0708-720. Nat Immunol. 2008. PMID: 18563081 No abstract available.
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The house that Jack built: expanding the concept of plasma cell niches.Am J Transplant. 2013 Mar;13(3):533. doi: 10.1111/ajt.12202. Am J Transplant. 2013. PMID: 23437878 No abstract available.
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